Flavonoids, Coumarins and Triterpenes from the Aerial Parts of Cnidoscolus texanus

Abstract

Phytochemical investigation on Cnidoscolus texanus led to the isolation of 26 compounds, which included 15 flavonoids (1 - 15), three coumarins (16 - 18), three coumaric acid derivatives (19 - 21), four triterpenoids (22 - 25), and one phytosterol (26). Among them, aromadendrin 7-O-(4′′-O-p-E-coumaroyl-β-glucopyranoside) (1), aromadendrin 7-O-(3′′,6′′-di-O-p-E-coumaroyl-β-glucopyranoside) (2), and naringenin 7-O-(4′′-O-p-Z-coumaroyl-β-glucopyranoside) (3) are new compounds. Their structures were determined by spectroscopic and chemical methods. All flavonoids were found to be inactive against DNA topoisomerase I.

Cnidoscolus texanus - Euphorbiaceae - flavonoids - topoisomerase I - coumarins - triterpenoids

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