A Novel Short and Efficient Synthetic Route to the Antimalarial Agent FR900098 and Derivatives

Johann Perruchon; Regina Ortmann; Martin Schlitzer

doi:10.1055/s-2007-990811

PAPER

A Novel Short and Efficient Synthetic Route to the Antimalarial Agent FR900098 and Derivatives

Johann Perruchon, Regina Ortmann, Martin Schlitzer*
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany
Fax: +49(6421)2825953; e-Mail: Schlitzer@staff.uni-marburg.de;

Abstract

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Abstract

We report here a new operationally simple, economical, and environmentally friendly multicomponent approach for a one-pot synthesis of the antimalarial agent FR900098. The reaction allows the fast construction of the compound from simple and commercially available substrates and reagents and is also applicable to the synthesis of modified derivatives of FR900098.

Key words

drugs - multicomponent reactions - sulfonamides - sulfones - phosphonic acid

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References

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