Synthesis, Table of Contents REVIEW © Georg Thieme Verlag Stuttgart · New York Applications of N-Chlorosuccinimide in Organic Synthesis W. Marek Gołebiewski*, Mirosław GucmaInstitute of Industrial Organic Chemistry, 6 Annopol St., 03-236 Warsaw, PolandFax: +48(22)8110799; e-Mail: golebiewski@ipo.waw.pl; Recommend Article Abstract Buy Article All articles of this category Abstract N-Chlorosuccinimide (NCS) is a versatile reagent and its significance is not limited to chlorination and oxidation. It mediates or catalyzes many chemical reactions, including halocyclizations, formation of heterocyclic systems, formation of new carbon-carbon bonds, rearrangements, and functional group transformations. 1 Introduction 2 Chlorinations 3 Replacement of Other Groups by Chlorine 4 Halocyclizations 5 Rearrangements and Functional Group Transformations 6 Formation of New Carbon-Carbon Bonds 7 Formation of Heterocyclic Systems 8 Oxidations 9 Deprotections 10 Transformations of NCS 11 Miscellaneous Reactions 12 Biological Activity of NCS 13 Conclusions Key words N-halosuccinimides - N-chlorosuccinimide - chlorination - oxidation - deprotection - rearrangement Full Text References References 1 Bender G. Chem. Ber. 1886, 19: 2268 2 Tscherniac J. Chem. Ber. 1901, 34: 4213 3 Zimmer A. J. Am. Chem. Soc. 1954, 76: 3856 4 Hirst M. J. Chem. Soc. 1922, 121: 2175 5 Bretheric L. Handbook of Reactive Chemical Hazards 5th ed.: Butterworth-Heinemann; London: 1995. 6 Tilstam U. Weinman H. Org. 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