Antibacterial Lignans and Triterpenoids from Rostellularia procumbens

Abstract

One new lignan, rostellulin A (1), four known lignans, justin B (2), justicidin C (3), cilinaphthalide A (4), and justicidin A (5), and four known triterpenoids, ursolic acid (6), euscaphic acid (7), 2α-hydroxyursolic acid (8), and tormentic acid (9), have been isolated from the whole plants of Rostellularia procumbens. Their structures were established on the basis of spectral data, including extensive NMR experiments. To our knowledge, compounds 6 - 9 are known compounds but not previously isolated from R. procumbens, 4 was previously reported from other Rostellularia species. Antibacterial activities of 1 - 9 were evaluated against eight bacterial strains with the agar dilution method, and they were found to possess antimicrobial activity with MIC values in the range of 1.56 - 100 μg/mL. None of the lignans exhibited cytotoxic activity against HCT-8 and Bel-7402 cells at concentrations up to 5 μg/mL.

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