Diketopiperazines and Phthalides from a Marine Derived Fungus of the Order Pleosporales

Abstract

Five metabolites, (Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3-methylsulfanylpiperazine-2,5-dione (1), (3S,3′R)-3-(3′-hydroxybutyl)-7-methoxyphthalide (2), (S)-3-butyl-7-methoxyphthalide (3), (3R,6R)-bisdethiodi(methylthio)hyalodendrin (4), and bis-N-norgliovictin (5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1, 3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 μg/mL.

Key words

Marine derived fungi - Pleosporales - diketopiperazines - phthalides - cytotoxicity

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