Pregnancy and Renal Tubular Acidosis

Thomas E. Rowe; Kevin Magee; F. Gary Cunningham

doi:10.1055/s-2007-993856

American Journal of Perinatology, Table of Contents

Am J Perinatol 1999; 16(4): 189-191
DOI: 10.1055/s-2007-993856

ORIGINAL ARTICLE

Pregnancy and Renal Tubular Acidosis

Thomas E. Rowe¹ , Kevin Magee² , F. Gary Cunningham³

¹The University of Texas Medical Branch at Galveston, Department of Obstetrics and Gynecology, Galveston, Texas
²Baylor University Medical Center, Department of Obstetrics and Gynecology
³The University of Texas Southwestern Medical Center at Dallas, Department of Obstetrics and Gynecology, Dallas, Texas

Abstract

ABSTRACT

Renal tubular acidosis (RTA) is uncommonly encountered in pregnancy. The risk for these women to develop pregnancy-induced hypertension has not been previously described. The renal defect noted in these women, aggravated by the normal hyperv-olemia of pregnancy, may predispose to hypertension. Three pregnancies in two women with RTA type 1 developed persistent diastolic hypertension in the third trimester. Mild renal insufficiency was noted in each woman as defined by serum creati-nine of 0.9-1.1 and 1.4-1.6 mg/dL, respectively. Vaginal delivery was achieved in each without complications. Blood pressures returned to normal following each pregnancy. Pregnancy-induced hypertension developed in each of three pregnancies in two patients with RTA type 1. The risk for these women to develop pregnancy-induced hypertension may be associated with the higher reported risk in women with underlying renal disease.

Keywords

Renal tubular acidosis (RTA) - pregnancy

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