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Am J Perinatol 1995; 12(6): 455-458
DOI: 10.1055/s-2007-994520
DOI: 10.1055/s-2007-994520
ORIGINAL ARTICLE
© 1995 by Thieme Medical Publishers, Inc.
In Utero Treatment of Fetal Goitrous Hypothyroidism Caused by Maternal Graves' Disease
Further Information
Publication History
Publication Date:
04 March 2008 (online)
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ABSTRACT
We present two cases of maternal Graves' disease complicated by fetal goitrous hypothyroidism. Both patients had elevated maternal thyroid-stimulating immunoglobulin and thyrotropic-binding inhibitory immunoglobulin antibody titers. Diagnosis of fetal hypothyroidism was made by cordocentesis, and serial injections of thyroxine into the amniotic fluid resulted in return to normal of fetal thyroid size and function at birth. Significance of in utero management of fetal hypothyroidism is discussed.
Keywords
Graves' - disease - fetal goitrous hypothyroidism - thyroxine - cardocentesis