ABSTRACT
Median clefts of the lower lip and mandible are very rare congenital anomalies. We
report a female infant born to nonconsanguineous parents with unilateral microphthalmia
and complete median clefting of the lower lip and mandible. This uncommon constellation
of congenital malformations has never been reported in a liveborn infant.
KEYWORDS
Clefting of mandible - microphthalmia - cleft of lower lip
REFERENCES
1
Couronné (of Rouen) A. Observation d'un bec-de-lièvre, compliqué de fentes à la voûte
palatine.
Ann Clin Soc Méd-Prat Montpellier.
1819;
6
107
2
Ranta R.
Incomplete median cleft of the lower lip associated with cleft palate, the Pierre
Robin anomaly or hypodontia.
Int J Oral Surg.
1984;
13
555-558
3
Lekkas C, Latief B S, Corputty J E.
Median cleft of the lower lip associated with lip pits and cleft of the lip and palate.
Cleft Palate Craniofac J.
1998;
35
269-271
4
Seyhan T, K4l4nr H.
Median cleft of the lower lip: report of two new cases and review of the literature.
Ann Otol Rhinol Laryngol.
2002;
111
217-221
5
Morton C B, Jordan H E.
Median cleft of lower lip and mandible, cleft sternum and absence of basihyoid: report
of case.
Arch Surg.
1935;
30
647-656
6
Iregbulem L M.
Median cleft of the lower lip: case report.
Plast Reconstr Surg.
1978;
61
787-789
7
Park S, Takushima A.
Median cleft of the lower lip, mandible and manubrium. A case report.
J Craniomaxillofac Surg.
1993;
21
189-191
8
Chidzonga M M, Shija J K.
Congenital median cleft of the lower lip, bifid tongue with ankyloglossia, cleft palate,
and submental epidermoid cyst: report of a case.
J Oral Maxillofac Surg.
1988;
46
809-812
9
Surendran N, Varghese B.
Midline cleft of the lower lip with cleft of the mandible and midline dermoid in the
neck.
J Pediatr Surg.
1991;
26
1387-1388
10
Ashley L M, Richardson G E.
Multiple congenital anomalies in a stillborn infant.
Anat Rec.
1943;
86
457-471
11
Waring III G O, Roth A M, Rodrigues M M.
Clinicopathologic correlation of microphthalmos with cyst.
Am J Ophthalmol.
1976;
82
714-721
12
Steiner R D, St J Dignan P, Hopkins R J, Kozielski R, Bove K E.
Combination of diaphragmatic eventration and microphthalmia/anophthalmia is probably
nonrandom.
Am J Med Genet.
2002;
108
45-50
13 Johnston M C, Bronsky P T, Millicobsky G.
Embryogenesis of cleft lip and palate . In McCarthy JC Plastic Surgery, Vol 4. Philadelphia; WB Saunders 1990: 2515-2552
14
Oostrom C A, Vermeij-Keers C, Gilbert P M, van der Meulen J C.
Median cleft of the lower lip and mandible: case reports, a new embryologic hypothesis,
and subdivision.
Plast Reconstr Surg.
1996;
97
313-320
15
Jabor M A, Cronin E D.
Bilateral cleft lip and palate and limb deformities: a presentation of amniotic band
sequence?.
J Craniofac Surg.
2000;
11
388-393
16 Moore K L, Persaud T VN, Shiota K. Color Atlas of Clinical Embryology. 2nd ed. Philadelphia;
WB Saunders 2000: 13-48
17
Lubinsky M.
VATER and other associations: historical perspectives and modern interpretations.
Am J Med Genet Suppl.
1986;
2
9-16
18
Iregbulem L M.
Median cleft of the lower lip.
Plast Reconstr Surg.
1978;
61
787-789
19
Surendran N, Varghese B.
Midline cleft of lower lip with cleft of the mandible and midline dermoid in the neck.
J Pediatr Surg.
1991;
26
1387-1388
20
Chidzonga M M, Lopez Perez V M, Mzezewa S.
Treatment of median cleft of the lower lip, mandible, and bifid tongue with ankyloglossia.
A case report.
Int J Oral Maxillofac Surg.
1996;
25
272-273
21
Sherman J E, Goulian D.
The successful one-stage surgical management of a midline cleft of the lower lip,
mandible, and tongue.
Plast Reconstr Surg.
1980;
66
756-759
Nahed O ElHassanM.D. M.P.H.
Assistant Professor of Pediatrics, Department of Pediatrics, Neonatology, University
of Arkansas for Medical Sciences, College of Medicine, Arkansas Children's Hospital
800 Marshall Street, Slot 512-5, Little Rock, AR 72202