Download PDF
Klin Monbl Augenheilkd 2009; 226(2): 115-119
DOI: 10.1055/s-2008-1027913
Klinische Studie

© Georg Thieme Verlag KG Stuttgart · New York

Vergleich von Spektral- und Zeit-Domänen-OCT hinsichtlich der automatisierten Erfassung der zentralen Netzhautdicke

Comparison of Spectral- and Time-Domain OCT in regard of the Automatic Detection of Central Retinal ThicknessS. C. Beutelspacher1 , J. M. Schmidbauer1
  • 1Augenklinik, Klinikum Nürnberg, Nürnberg
Further Information

Publication History

Eingegangen: 3.8.2008

Angenommen: 15.10.2008

Publication Date:
10 February 2009 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Hintergrund: Es wurde die automatische Erfassung der zentralen Netzhautdicke durch ein StratusOCT (Zeiss, Deutschland) und ein Spectralis-HRA-OCT-System (Heidelberg Engineering, Deutschland) verglichen. Material und Methoden: 50 Patienten (25 Frauen und 25 Männer) werden in die Studie eingeschlossen. In allen Fällen wurden beide Augen gemessen. Es erfolgten konsekutive Messungen an beiden Geräten. Die zentrale und regional verteile Netzhautdicke wurde aus beiden Geräten automatisiert berechnet und die Übereinstimmung der Messergebnisse mittels Bland-Altmann-Analyse untersucht. Ergebnisse: Die foveale Netzhautdicke war beim Spectralis-HRA-OCT signifikant größer als beim StratusOCT (p < 0,01). Schlussfolgerung: Sowohl Time-Domain- als auch Spectral-Domain-OCT-Geräte liefern verlässliche Daten hinsichtlich der automatisierten Erfassung der Netzhautdicke. Die Spectral-Domain-OCT-Maschine liefert jedoch signifikant dickere Werte für die zentrale Netzhautdicke als die Time-Domain-Maschine. Entsprechend können die Messwerte aus beiden Maschinen nicht direkt verglichen werden.

Abstract

Background: The aim of this study was to compare macular thickness measurements obtained from time-domain optical coherence tomography (OCT) and spectral-domain OCT to evaluate their agreement. Materials and Methods: Fifty randomly assigned subjects were included. Twenty-five were male, twenty-five female. In all cases both eyes were measured. Serial measurements were obtained from time-domain (StratusOCT, Zeiss) and spectral-domain OCT (Heidelberg Engineering, Germany). Total and regional macular thicknesses were obtained from both machines. Their agreement was estimated by Bland Altman plots. Results: The foveal and total macular thicknesses measured by 3D OCT were significantly greater than those measured by Stratus OCT (p < 0.001). Conclusions: While both time-domain and spectral-domain OCTs are reliable for macular thickness measurements, spectral-domain OCT delivers significantly higher values for macular thickness compared to the time-domain OCT. Macular measurements obtained from the two OCT systems may not be used interchangeably.

Schlüsselwörter

Retina - physiologische Optik - Informationstechnologie

Key words

retina - physiological optics - information technology

Literatur

  • 1 Anger E M, Unterhuber A, Hermann B. et al . Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections.  Exp Eye Res. 2004;  78 1117-1125
    Google Scholar
  • 2 Bland J M, Altman D G. Statistical methods for assessing agreement between two methods of clinical measurement.  Lancet. 1986;  1 307-310
    Google Scholar
  • 3 Choi S S, Zawadzki R J, Greiner M A. et al . Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen.  J Neuroophthalmol. 2008;  28 120-125
    Google Scholar
  • 4 Fleckenstein M, Charbel Issa P, Helb H M. et al . High resolution Spectral Domain-OCT imaging in Geographic Atrophy associated with Age-related Macular Degeneration.  Invest Ophthalmol Vis Sci. 2008;  49 4137-4144
    Google Scholar
  • 5 Hu Z, Rollins A M. Fourier domain optical coherence tomography with a linear-in-wavenumber spectrometer.  Opt Lett. 2007;  32 3525-3527
    Google Scholar
  • 6 Ip L P, Nguyen T Q, Bartsch D U. Fundus based eye tracker for optical coherence tomography.  Conf Proc IEEE Eng Med Biol Soc. 2004;  2 1505-1508
    Google Scholar
  • 7 Ko T H, Fujimoto J G, Duker J S. et al . Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair.  Ophthalmology. 2004;  111 2033-2043
    Google Scholar
  • 8 Ko T H, Fujimoto J G, Schuman J S. et al . Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology.  Ophthalmology. 2005;  112 1922 e1921-e1915
    Google Scholar
  • 9 Kozak I, Morrison V L, Clark T M. et al . Discrepancy between fluorescein angiography and optical coherence tomography in detection of macular disease.  Retina. 2008;  28 538-544
    Google Scholar
  • 10 Leitgeb R A. Optical coherence tomography – high resolution imaging of structure and function.  Conf Proc IEEE Eng Med Biol Soc. 2007;  2007 530-532
    Google Scholar
  • 11 Lim J I, Tan O, Fawzi A A. et al . A pilot study of Fourier-domain optical coherence tomography of retinal dystrophy patients.  Am J Ophthalmol. 2008;  146 417-426
    Google Scholar
  • 12 Meyer C H, Rodrigues E B, Mennel S. et al . Functional and anatomical investigations in racemose haemangioma.  Acta Ophthalmol Scand. 2007;  85 764-771
    Google Scholar
  • 13 Mumcuoglu T, Wollstein G, Wojtkowski M. et al . Improved visualization of glaucomatous retinal damage using high-speed ultrahigh-resolution optical coherence tomography.  Ophthalmology. 2008;  115 782-789, e782
    Google Scholar
  • 14 Pircher M, Zawadzki R J, Evans J W. et al . Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography.  Opt Lett. 2008;  33 22-24
    Google Scholar
  • 15 Ruggeri M, Wehbe H, Jiao S. et al . In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography.  Invest Ophthalmol Vis Sci. 2007;  48 1808-1814
    Google Scholar
  • 16 Scholda C, Wirtitsch M, Hermann B. et al . Ultrahigh resolution optical coherence tomography of macular holes.  Retina. 2006;  26 1034-1041
    Google Scholar
  • 17 Unterhuber A, Povazay B, Bizheva K. et al . Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomography.  Phys Med Biol. 2004;  49 1235-1246
    Google Scholar
  • 18 Wolf-Schnurrbusch U E, Enzmann V, Brinkmann C K. et al . Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination.  Invest Ophthalmol Vis Sci. 2008;  49 3095-3099
    Google Scholar
  • 19 Yamaike N, Tsujikawa A, Ota M. et al . Three-dimensional imaging of cystoid macular edema in retinal vein occlusion.  Ophthalmology. 2008;  115 355-362 e352
    Google Scholar
  • 20 Zawadzki R J, Choi S S, Jones S M. et al . Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions.  J Opt Soc Am A Opt Image Sci Vis. 2007;  24 1373-1383
    Google Scholar

Dr. Sven C. Beutelspacher

Augenklinik Klinikum Nürnberg

Prof. Ernst-Nathan-Str. 1

90419 Nürnberg

Phone: ++ 49/911/398-26 68

Fax: ++ 49/911/398-32 91

Email: sven.beutelspacher@klinikum-nuernberg.de

      >