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Thorac Cardiovasc Surg 2009; 57(5): 309-311
DOI: 10.1055/s-2008-1038634
Case Reports

© Georg Thieme Verlag KG Stuttgart · New York

The Potential Protective Effect of Low Potassium Dextran against Lipid Peroxidation in a Rat Lung Transplantation Model

R. L. Torres1 , L. K. Martins2 , M. Picoral3 , J. Auzani4 , T. R. G. Fernandes3 , I. L. S. Torres4 , M. B. C. Ferreira4 , C. F. Andrade5 , A. Belló-Klein3 , P. F. G. Cardoso5
  • 1Respirology, Porto Alegre General Hospital, Porto Alegre, Brazil
  • 2Cardiovascular Surgery, Heart Institute, Porto Alegre, Brazil
  • 3Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
  • 4Pharmacology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
  • 5Thoracic Surgery, Hospital de Clinicas Porto Alegre, Porto Alegre, Brazil
Further Information

Publication History

received January 20, 2008

Publication Date:
23 July 2009 (online)

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Abstract

The overproduction of reactive oxygen species plays an important role in the cascade of events during lung ischemia-reperfusion leading to graft failure. An evaluation of the peripheral markers of oxidative stress and antioxidant enzyme activities was carried out after reperfusion in a rat lung transplant model. The decrease in lipid peroxidation immediately after transplantation (p < 0.05) may suggest an adaptative response and/or a protective effect of low potassium dextran against lipid peroxidation through natural scavenging mechanisms.

Key words

Thoracic surgery - heart and lung transplantation - cardiovascular surgery

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Dr. MD, PhD Cristiano Feijó Andrade

Thoracic Surgery
Hospital de Clinicas Porto Alegre

Ramiro Barcelos 2350

900035-903 Porto Alegre – RS

Brazil

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