The Potential Protective Effect of Low Potassium Dextran against Lipid Peroxidation in a Rat Lung Transplantation Model

Abstract

The overproduction of reactive oxygen species plays an important role in the cascade of events during lung ischemia-reperfusion leading to graft failure. An evaluation of the peripheral markers of oxidative stress and antioxidant enzyme activities was carried out after reperfusion in a rat lung transplant model. The decrease in lipid peroxidation immediately after transplantation (p < 0.05) may suggest an adaptative response and/or a protective effect of low potassium dextran against lipid peroxidation through natural scavenging mechanisms.

Key words

Thoracic surgery - heart and lung transplantation - cardiovascular surgery

References

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