Tris(pentafluorophenyl)borane-Catalyzed Three-Component Reaction for the Synthesis of 1,8-Dioxodecahydroacridines under Solvent-Free Conditions

Abstract

A mild and efficient method for the synthesis of 1,8-dioxodecahydroacridines has been developed. The synthesis proceeds via a three-component reaction of a 1,3-dione, an aldehyde and an amine, under solvent-free conditions, catalyzed by tris(pentafluorophenyl)borane [B(C₆F₅)₃]. The mildness of the catalyst was demonstrated­ by studying the reaction of 1,3-cyclohexanedione with various aldehydes and amines which gave the 1,8-dioxodecahydroacridines in high yields.

Key words

Hantzsch reaction - acridinediones - tris(pentafluorophenyl)borane - three-component reaction - Lewis acid

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