Download PDF
Synthesis 2008(13): 2100-2104  
DOI: 10.1055/s-2008-1067109
PAPER
© Georg Thieme Verlag Stuttgart · New York

Vanadium-Salan Catalyzed Enantioselective Ring Opening of meso-Epoxides with Aromatic Amines

Jiangtao Sun*a,b, Zhenya Daia,c, Minghua Yanga, Xu Pana, Chengjian Zhu*a,d
a School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. of China
Fax: +86(21)51903505; e-Mail: jtsun@sundia.com;
b Department of Chemistry, Sundia Meditech (Shanghai) Co, Ltd, Shanghai 201203, P. R. of China
c School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. of China
d State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, P. R. of China
Further Information

Publication History

Received 25 March 2008
Publication Date:
21 May 2008 (online)

    Permissions and Reprints All articles of this category

Abstract

The first example of enantioselective ring-opening of meso-epoxides catalyzed by chiral oxovanadium(V)-salan complexes is reported. The reaction furnished 1,2-aminoalcohols in good yields and moderate to high enantioselectivities (up to 87%).

Key words

amine - asymmetric catalysis - epoxides - ring-opening - vanadium