Molekulare Pathologie der multiplen Sklerose: ein Überblick

Zusammenfassung

Die Pathogenese der multiplen Sklerose ist heterogen und komplex. Pathologische Veränderungen im Gehirn von MS-Patienten spielen sich nicht nur in den fokalen Läsionen der weißen Substanz ab. Die normal erscheinende weiße Substanz sowie die graue Substanz sind in den globalen Entzündungsprozess miteinbezogen und tragen zu klinischen Befunden und bildgebenden Charakteristika bei.

Abstract

The pathogenesis of multiple sclerosis is heterogenous and complex. Pathological changes in the brains of multiple sclerosis patients occur not only in focal lesions of the white matter. Rather, the normal-appearing white matter as well as the grey matter are included in the global inflammatory process and contribute also to the clinical findings and imaging characteristics.

Schlüsselwörter

multiple Sklerose - Pathologie - Immunpathogenese

Key words

multiple sclerosis - pathology - immunopathogenesis

Literatur

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