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Aktuelle Neurologie 2008; 35(4): 155-159
DOI: 10.1055/s-2008-1067371
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Molekulare Pathologie der multiplen Sklerose: ein Überblick

Molecular Pathology of Multiple Sclerosis: An OverviewW.  Brück1
  • 1Institut für Neuropathologie, Universitätsmedizin Göttingen, Georg-August-Universität
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Publication History

Publication Date:
05 May 2008 (online)

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Zusammenfassung

Die Pathogenese der multiplen Sklerose ist heterogen und komplex. Pathologische Veränderungen im Gehirn von MS-Patienten spielen sich nicht nur in den fokalen Läsionen der weißen Substanz ab. Die normal erscheinende weiße Substanz sowie die graue Substanz sind in den globalen Entzündungsprozess miteinbezogen und tragen zu klinischen Befunden und bildgebenden Charakteristika bei.

Abstract

The pathogenesis of multiple sclerosis is heterogenous and complex. Pathological changes in the brains of multiple sclerosis patients occur not only in focal lesions of the white matter. Rather, the normal-appearing white matter as well as the grey matter are included in the global inflammatory process and contribute also to the clinical findings and imaging characteristics.

Schlüsselwörter

multiple Sklerose - Pathologie - Immunpathogenese

Key words

multiple sclerosis - pathology - immunopathogenesis

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Prof. Dr. med. Wolfgang Brück

Institut für Neuropathologie, Universitätsmedizin Göttingen, Georg-August-Universität

Robert-Koch-Str. 40

37075 Göttingen

Email: wbrueck@med.uni-goettingen.de