Zusammenfassung
Abgesehen von der Wiedereinführung eines monoklonalen Antikörpers gegen das Adhäsionsmolekül α4-Integrin, Natalizumab, hat sich an der Behandlung der multiplen Sklerose in der jüngeren Vergangenheit wenig geändert. Es befinden sich jedoch eine Reihe neuer Therapieansätze in vorklinischer und klinischer Entwicklung. Neben oral zu verabreichenden Substanzen in fortgeschrittenen Phase-III-Studien zählen hierzu monoklonale Antikörper gegen eine Vielzahl spezifischer Moleküle, Peptide, DNA-Vakzinierungen und zelltherapeutische Ansätze. Neuroprotektive oder gar neuroreparative Ansätze werden das Behandlungsrepertoire in Zukunft voraussichtlich ergänzen, und es gibt erste Ansätze in Richtung rationaler Kombinationsbehandlungen und auf den einzelnen Patienten ausgerichtete Therapieschemata.
Abstract
Apart from the reintroduction of a monoclonal antibody against the adhesion molecule α4 integrin, Natalizumab, little has changed in the treatment of multiple sclerosis in the recent past. However, a series of novel therapeutic approaches are in preclinical and advanced phase III clinical development. Besides orally administered compounds this includes monoclonal antibodies against a panel of specific molecules, peptides, DNA vaccinations and cell therapy approaches. Neuroprotective and even neuroreparative strategies may complement the therapeutic armamentarium in the future, and there are first attempts towards rational combination therapies and treatment schemes that are directed at the individual patient.
Schlüsselwörter
multiplen Sklerose - zukünftige Therapien - Natalizumab - monoklonale Antikörper
Key words
multiple sclerosis - future therapeutic options - Natalizumab - monoclonal antibodies
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1 Gefördert durch die Gemeinnützige Hertie Stiftung.
Prof. Roland Martin
Zentrum für Molekulare Neurobiologie Hamburg (ZMNH), Universitätsklinikum Eppendorf
Falkenried 94
20251 Hamburg
eMail: roland.martin@zmnh.uni-hamburg.de
