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Characteristic
Spectroscopic Data of the 2-Oxygenated and 2,7-Dioxygenated Carbazole
Alkaloids2-Methoxy-3-methylcarbazole
(4)
Colorless
crystals; mp 221 ˚C (lit.¹¹ 223 ˚C).
UV (MeOH): λmax = 230,
237, 257, 264 (sh), 301, 331 nm. IR (ATR): ν = 3402,
2992, 2919, 2851, 1631, 1609, 1496, 1455, 1340, 1304, 1230, 1194,
1175, 1139, 1109, 1038, 1014, 1003, 885, 819, 766, 749, 725 cm-¹. ¹H
NMR (500 MHz, acetone-d
6): δ = 2.32
(s, 3 H), 3.89 (s, 3 H), 7.02 (s, 1 H), 7.12 (t, J = 7.8 Hz,
1 H), 7.27 (t, J = 7.8
Hz, 1 H), 7.43 (d, J = 7.8
Hz, 1 H), 7.82 (s, 1 H), 7.97 (d, J = 7.8
Hz, 1 H), 10.05 (br s, 1 H). ¹³C NMR
and DEPT (125 MHz, acetone-d
6): δ = 16.87
(CH3), 55.68 (CH3), 93.35 (CH), 111.27 (CH),
116.73 (C), 118.95 (C), 119.43 (CH), 119.79 (CH), 121.94 (CH), 124.14
(C), 124.60 (CH), 140.61 (C), 140.74 (C), 158.20 (C). MS (EI): m/z (%) = 211
(100) [M+], 210 (11), 196
(77), 180 (7), 168 (25), 167 (35), 166 (10). Anal. Calcd (%)
for C14H13NO: C, 79.59; H, 6.20; N, 6.63.
Found: C, 79.12; H, 6.64; N, 6.13.
Glycosinine
(
O
-Methylmukonal)
(5)
Colorless crystals; mp 196-198 ˚C
(lit.¹² 189.0-189.5 ˚C, lit.¹³ 185 ˚C).
UV (MeOH): λmax = 235,
243 (sh), 276, 295, 351 nm. IR (ATR): ν = 3323,
2922, 2851, 1664, 1603, 1575, 1487, 1460, 1436, 1412, 1381, 1345,
1328, 1309, 1259, 1244, 1200, 1169, 1145, 1030, 974, 917, 901, 854,
841, 764, 744, 724 cm-¹. ¹H
NMR (500 MHz, acetone-d
6): δ = 4.02
(s, 3 H), 7.16 (s, 1 H), 7.22 (t, J = 7.8
Hz, 1 H), 7.37 (t, J = 7.8 Hz,
1 H), 7.49 (d, J = 7.8
Hz, 1 H), 8.14 (d, J = 7.8
Hz, 1 H), 8.51 (s, 1 H), 10.46 (s, 1 H), 10.66 (br s, 1 H). ¹³C
NMR and DEPT (75 MHz, acetone-d
6): δ = 56.32
(CH3), 93.78 (CH), 111.89 (CH), 117.95 (C), 119.58 (C),
120.74 (CH), 120.95 (CH), 121.35 (CH), 124.38 (C), 126.37 (CH),
141.61 (C), 146.43 (C), 162.37 (C), 188.57 (CHO). MS (EI): m/z (%) = 225
(100) [M+], 224 (26), 210
(9), 209 (14), 208 (22), 196 (8), 180 (21), 179 (42), 168 (21),
154 (28). Anal. Calcd (%) for C14H11NO2:
C, 74.65; H, 4.92; N, 6.22. Found: C, 74.77; H, 4.98; N, 6.19.
Clausine L
(6)
Colorless
crystals; mp 172-173 ˚C (lit.8 133-135 ˚C;
lit.9 204-205 ˚C). UV (MeOH): λmax = 235,
241, 269, 282 (sh), 319, 333 nm. IR (ATR): ν = 3264,
2951, 2922, 2852, 1690, 1632, 1608, 1574, 1486, 1462, 1427, 1392,
1348, 1313, 1278, 1239, 1201, 1163, 1115, 1082, 1035, 979, 950,
909, 875, 825, 789, 775, 766, 750, 727 cm-¹. ¹H
NMR (500 MHz, acetone-d
6): δ = 3.85
(s, 3 H), 3.92 (s, 3 H), 7.15 (s, 1 H), 7.20 (t, J = 7.8
Hz, 1 H), 7.35 (t, J = 7.8
Hz, 1 H), 7.49 (d, J = 7.8
Hz, 1 H), 8.09 (d, J = 7.8
Hz, 1 H), 8.54 (s, 1 H), 10.53 (br s, 1 H). ¹³C
NMR and DEPT (75 MHz, acetone-d
6): δ = 51.77
(CH3), 56.44 (CH3), 94.85 (CH), 111.83 (CH), 113.76
(C), 116.97 (C), 120.47 (CH), 120.63 (CH), 124.19 (C), 124.99 (CH),
126.00 (CH), 141.53 (C), 144.70 (C), 159.83 (C), 167.45 (C=O).
MS (EI): m/z (%) = 255
(100) [M+], 240 (5), 224 (89),
209 (18), 194 (9), 181 (7), 166 (14), 153 (15), 139 (11). HRMS: m/z calcd
for C15H13NO3 [M+]: 255.0895;
found: 255.0889.
Mukonidine
(3)
Colorless crystals; mp 189 ˚C
(lit.8 168-170 ˚C; lit.¹0 188 ˚C).
UV (MeOH): λmax = 235,
243, 270 (sh), 276 (sh), 284, 325, 338 nm. IR (ATR): ν = 3347,
2952, 2922, 2852, 1644, 1627, 1582, 1481, 1464, 1432, 1373, 1363,
1329, 1258, 1236, 1189, 1165, 1118, 1093, 1014, 991, 949, 898, 871,
821, 784, 762, 740, 719 cm-¹. ¹H
NMR (500 MHz, acetone-d
6): δ = 4.00
(s, 3 H), 6.93 (s, 1 H), 7.20 (t, J = 7.8 Hz,
1 H), 7.36 (t, J = 7.8
Hz, 1 H), 7.47 (d, J = 7.8
Hz, 1 H), 8.09 (d, J = 7.8
Hz, 1 H), 8.62 (s, 1 H), 10.52 (br s, 1 H), 11.07 (s, 1 H). ¹³C
NMR and DEPT (75 MHz, acetone-d
6): δ = 52.60
(CH3), 97.70 (CH), 105.95 (C), 111.79 (CH), 117.85 (C),
120.58 (CH), 120.89 (CH), 123.41 (CH), 124.30 (C), 126.51 (CH),
141.96 (C), 146.62 (C), 161.62 (C), 172.22 (C=O). MS (EI): m/z (%) = 241
(46) [M+], 209 (100), 181
(20), 153 (33), 126 (10), 104 (10).
Isomukonidine (13)
Colorless crystals; mp 226 ˚C
(decomp.) (‘Chakraborty’s mukonidine’,
lit.7 245 ˚C). UV (EtOH): λmax = 235,
241, 269, 278 (sh), 281, 320, 334 nm. IR (ATR): ν = 3206,
3180, 2922, 2851, 1702, 1625, 1608, 1582, 1492, 1459, 1439, 1357,
1328, 1303, 1246, 1224, 1192, 1159, 1078, 1024, 1010, 968, 914,
874, 819, 778, 764, 751, 716 cm-¹. ¹H
NMR (500 MHz, acetone-d
6): δ = 4.13
(s, 3 H), 7.24 (t, J = 7.8
Hz, 1 H), 7.27 (s, 1 H), 7.39 (t, J = 7.8
Hz, 1 H), 7.51 (d, J = 7.8 Hz,
1 H), 8.16 (d, J = 7.8
Hz, 1 H), 8.77 (s, 1 H), 10.62 (br s, 1 H), 10.88 (br s, 1 H). ¹³C
NMR and DEPT (125 MHz, acetone-d
6): δ = 57.08
(CH3), 94.56 (CH), 111.62 (C), 111.88 (CH), 118.10 (C),
120.72 (CH), 120.84 (CH), 123.97 (C), 126.24 (CH), 126.37 (CH),
141.58 (C), 145.02 (C), 158.90 (C), 166.56 (C=O). MS (EI): m/z (%) = 241
(100) [M+], 226 (5), 224 (9),
194 (5), 182 (11), 168 (6), 154 (14), 153 (6). Anal. Calcd (%)
for C14H11NO3: C, 69.70; H, 4.60; N,
5.81. Found: C, 69.84; H, 4.81; N, 5.92.
3-Cyano-7-hydroxy-2-methoxycarbazole (19)
Colorless crystals; mp 251-252 ˚C.
UV (MeOH): λmax = 220,
244, 282, 322, 336 nm. IR (ATR): ν = 3529, 3385,
3364, 3324, 3205, 2923, 2841, 2219, 1612, 1574, 1474, 1450, 1429,
1400, 1357, 1322, 1283, 1263, 1243, 1202, 1143, 1115, 1026, 954,
899, 845, 819, 810, 721 cm-¹. ¹H
NMR (500 MHz, acetone-d
6): δ = 3.97
(s, 3 H), 6.79 (dd, J = 8.4,
2.1 Hz, 1 H), 6.94 (d, J = 2.1
Hz, 1 H), 7.14 (s, 1 H), 7.89 (d, J = 8.4
Hz, 1 H), 8.21 (s, 1 H), 8.47 (br s, 1 H), 10.45 (br s, 1 H). ¹³C
NMR and DEPT (125 MHz, acetone-d
6): δ = 56.43
(CH3), 93.45 (C), 94.23 (CH), 97.72 (CH), 110.21 (CH),
116.10 (C), 118.26 (C), 118.47 (C), 121.41 (CH), 125.36 (CH), 142.88
(C), 144.55 (C), 157.40 (C), 159.90 (C). Anal. Calcd (%)
for C14H10N2O2: C, 70.58;
H, 4.23; N, 11.76. Found: C, 70.99; H, 4.71; N, 11.30.
3-Cyano-2,7-dihydroxycarbazole
(20)
Colorless crystals; mp >260 ˚C
(decomp.). UV (MeOH): λmax = 220,
244, 277, 282, 323, 337 nm. IR (ATR): ν = 3349, 3315,
2921, 2851, 2218, 1613, 1475, 1448, 1420, 1393, 1326, 1283, 1216,
1190, 1145, 987, 953, 882, 844, 822, 806, 789, 752, 724 cm-¹. ¹H
NMR (500 MHz, acetone-d
6): δ = 6.77
(dd, J = 8.4,
2.1 Hz, 1 H), 6.91 (d, J = 2.1
Hz, 1 H), 7.05 (s, 1 H), 7.88 (d, J = 8.4
Hz, 1 H), 8.16 (s, 1 H), 8.46 (br s, 1 H), 9.44 (br s, 1 H), 10.29
(br s, 1 H). ¹³C NMR and DEPT (125
MHz, acetone-d
6): δ = 92.51
(C), 97.62 (CH), 97.82 (CH), 110.06 (CH), 116.31 (C), 118.45 (C),
118.80 (C), 121.34 (CH), 124.87 (CH), 143.15 (C), 144.93 (C), 157.49
(C), 157.92 (C).
7-Hydroxy-
O
-methylmukonal (22)
Light yellow crystals; mp >240 ˚C
(decomp.). UV (MeOH): λmax = 223,
242, 284 (sh), 300, 348 nm. IR (ATR): ν = 3384, 3310,
2920, 2846, 1655, 1603, 1583, 1498, 1469, 1400, 1364, 1320, 1236,
1199, 1157, 1104, 1036, 953, 921, 907, 860, 842, 817, 800, 745,
735 cm-¹. ¹H NMR
(500 MHz, acetone-d
6): δ = 3.99
(s, 3 H), 6.79 (dd, J = 8.4,
2.1 Hz, 1 H), 6.94 (d, J = 2.1
Hz, 1 H), 7.08 (s, 1 H), 7.92 (d, J = 8.4
Hz, 1 H), 8.35 (s, 1 H), 8.45 (br s, 1 H), 10.41 (br s, 1 H), 10.44 (s,
1 H). ¹³C NMR and DEPT (125 MHz, acetone-d
6): δ = 56.26
(CH3), 93.69 (CH), 98.04 (CH), 110.15 (CH), 117.14 (C),
118.49 (C), 119.25 (C), 119.79 (CH), 121.49 (CH), 143.23 (C), 146.54
(C), 157.47 (C), 161.59 (C), 188.56 (CHO). Anal. Calcd (%)
for C14H11NO3: C, 69.70; H, 4.60;
N, 5.81. Found: C, 69.89; H, 4.84; N, 5.44.
Clausine
V
(9)
Colorless crystals;
mp >270 ˚C (decomp.) (lit.¹5 228-230 ˚C;
lit.³³ 272-274 ˚C).
UV (MeOH): λmax = 224
(sh), 227, 231, 236 (sh), 238, 259, 311, 319 nm. IR (ATR): ν = 3378,
2937, 2837, 1607, 1573, 1502, 1453, 1323, 1263, 1230, 1198, 1156,
1118, 1025, 934, 823, 803, 728 cm-¹. ¹H NMR
(500 MHz, acetone-d
6): δ = 3.84
(s, 6 H), 6.76 (dd, J = 8.5,
2.2 Hz, 2 H), 6.98 (d, J = 2.2
Hz, 2 H), 7.84 (d, J = 8.5
Hz, 2 H), 10.07 (br s, 1 H). ¹³C NMR
and DEPT (125 MHz, acetone-d
6): δ = 55.66
(2 CH3), 95.55 (2 CH), 108.37 (2 CH), 117.97 (2 C), 120.59
(2 CH), 142.27 (2 C), 159.11 (2 C). MS (EI): m/z (%) = 227
(100) [M+], 212 (92), 184 (19),
169 (17), 141 (6). Anal. Calcd (%) for C14H13NO2:
C, 73.99; H, 5.77; N, 6.16. Found: C, 73.55; H, 6.16; N, 6.68.
24
Lafrance M.
Fagnou K.
J. Am. Chem. Soc.
2006,
128:
16496
25
Crystal Data for
Glycosinine
(5)
C14H11NO2,
crystal size: 0.34 × 0.21 × 0.09
mm³, M = 225.24
g mol-¹, monoclinic, space group: P21/c, λ = 0.71073 Å, a = 11.235
(1), b = 13.717
(1), c = 7.259
(2) Å, β = 106.38
(1)˚, V = 1073.3
(3) ų, Z = 4, D
calcd = 1.394
g
cm-³, µ = 0.094
mm-¹, T = 198
(2) K, θ range = 3.28-30.00˚;
reflections collected: 26896, independent: 3108 (R
int = 0.0999),
159 parameters. The structure was solved by direct methods and refined
by full-matrix least-squares on F
²;
final R indices [I > 2σ(I)]: R1 = 0.0514, wR2 = 0.1018; maximal
residual electron density: 0.273 e Å-³.
CCDC-686500 contains the supplementary crystallographic data for this
paper. These data can be obtained free of charge from The Cambridge
Crystallographic Data Centre via www.ccdc.cam.uk/data_request/cif.
26a Manganese
dioxide (precipitated, active) from Merck (art. 805958).
26b
Corey EJ.
Gilman NW.
Ganem BE.
J. Am. Chem. Soc.
1968,
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Knölker H.-J.
J. Prakt. Chem.
1995,
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27
Crystal Data for
Isomukonidine
(13)
C14H11NO3,
crystal size: 0.32 × 0.29 × 0.28
mm³, M = 241.24
g mol-¹, monoclinic, space group: C2/c, λ = 0.71073 Å, a = 16.423
(3), b = 7.5231
(15), c = 18.548 (4) Å, β = 96.25
(3)˚, V = 2278.1
(8) ų, Z = 8, D
calcd = 1.407 g
cm-³, µ = 0.100
mm-¹, T = 298
(2) K, θ range = 3.13-30.02˚;
reflections collected: 34016, independent: 3328 (R
int = 0.0590),
168 parameters. The structure was solved by direct methods and refined
by full-matrix least-squares on F
²;
final R indices [I > 2σ(I)]: R1 = 0.0430, wR2 = 0.1125; maximal
residual electron density: 0.316 e Å-³.
CCDC-686501 contains the supplementary crystallographic data for this
paper. These data can be obtained free of charge from The Cambridge
Crystallographic Data Centre via www.ccdc.cam.uk/data_request/cif.
28
Sridharan V.
Martín MA.
Menéndez JC.
Synlett
2006,
2375
29
Experimental Procedure
for the Microwave-Assisted Palladium(II)-Catalyzed Oxidative Cyclization
The
diarylamine 16 (400 mg, 1.01 mmol), Pd(OAc)2 (46.3 mg,
0.21 mmol), Cu(OAc)2 (458 mg, 2.52 mmol), and pivalic
acid (4.7 g) were heated in a 10 mL microwave vessel for 2 h at
130 ˚C. The reaction mixture was extracted with
a sat. solution of K2CO3 until the aqueous
layer showed no further blue color. The aqueous layer was extracted
with Et2O and the combined organic layers were dried
with MgSO4. Removal of the solvent in vacuum and flash chromatography
(PE-Et2O, gradient elution from 4:1 to 1:1) of
the crude product on SiO2 provided 3-cyano-7-triiso-propylsilyloxy-4-methoxycarbazole
(18) (yield 17.0 mg, 4%) as colorless
crystals (mp 141-143 ˚C), then the diarylamine 16 (yield 28.2 mg, 7%) as colorless
crystals, and, as the most polar fraction, 3-cyano-7-triisoprop-ylsilyloxy-2-methoxycarbazole
(17) (yield 266.0 mg, 67%) as
colorless crystals (mp 180-181 ˚C).
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Olah GA.
Narang SC.
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