A prospective and randomized comparison of the safety and effects of therapeutic levels of enoxaparin versus unfractionated heparin in chronically anticoagulated patients undergoing elective cardiac catheterization

Heyder Omran; Christoph Hammerstingl; Harald Schmidt; Giso von der Recke; Wilhelm Dieter Paar; Berndt Lüderitz

doi:10.1160/TH02-10-0159

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2003; 90(02): 267-271
DOI: 10.1160/TH02-10-0159

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

A prospective and randomized comparison of the safety and effects of therapeutic levels of enoxaparin versus unfractionated heparin in chronically anticoagulated patients undergoing elective cardiac catheterization

Autor*innen

Heyder Omran

¹Department of Medicine Cardiology, University of Bonn, Bonn, Germany
Christoph Hammerstingl

¹Department of Medicine Cardiology, University of Bonn, Bonn, Germany
Harald Schmidt

¹Department of Medicine Cardiology, University of Bonn, Bonn, Germany
Giso von der Recke

¹Department of Medicine Cardiology, University of Bonn, Bonn, Germany
Wilhelm Dieter Paar

²Aventis Pharma GmbH, Bad Soden, Germany
Berndt Lüderitz

¹Department of Medicine Cardiology, University of Bonn, Bonn, Germany

Abstract

Summary

Consecutive patients with atrial fibrillation and/or prosthetic heart valves, receiving chronic anticoagulation with phenprocoumon and scheduled to undergo cardiac catheterization, were randomized to subcutaneous enoxaparin twice daily (n = 32) or intravenous UFH (n = 36). Cardiac catheterization was performed at an international normalized ratio <1.5. Activated partial thromboplastin times and levels of anti-Factor Xa activity were measured daily. The time until effective anticoagulation (primary endpoint) was significantly shorter for enoxaparin than for UFH (1.1 ± 0.4 days versus 3.7 ± 2.5 days, p <0.0001). The percentage of days of effective anticoagulation was significantly higher in the enoxaparin group than in the UFH group (93.3 ± 9.5% versus 53.7 ± 26.6%, p <0.0001). In conclusion, enoxaparin achieves therapeutic levels of anticoagulation more rapidly and consistently than UFH in chronically anticoagulated patients with prosthetic heart valves and/or atrial fibrillation undergoing cardiac catheterization.

Keywords

Low-molecular-weight heparin - enoxaparin - chronic oral anticoagulation - cardiac catheterization - unfractionated heparin

Volltext

Referenzen

References
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