Hemostatic risk factors in ischemic stroke

Franziska Demarmels Biasiutti; Daniela Berger; Heinrich P. Mattle; Bernhard Lämmle; Walter A. Wuillemin

doi:10.1160/TH03-03-0134

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2003; 90(06): 1094-1099
DOI: 10.1160/TH03-03-0134

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Hemostatic risk factors in ischemic stroke

Authors

Franziska Demarmels Biasiutti

¹Central Hematology Laboratory, Inselspital, University of Bern, Switzerland
Daniela Berger

¹Central Hematology Laboratory, Inselspital, University of Bern, Switzerland
Heinrich P. Mattle

²Department of Neurology, Inselspital, University of Bern, Switzerland
Bernhard Lämmle

¹Central Hematology Laboratory, Inselspital, University of Bern, Switzerland
Walter A. Wuillemin

¹Central Hematology Laboratory, Inselspital, University of Bern, Switzerland

³Division of Hematology, Department of Internal Medicine, Kantonsspital Lucerne, Switzerland

Abstract

Summary

The role played by hemostasis in the pathogenesis of ischemic stroke is still controversial. In the present study, we looked for a possible association of ischemic stroke and high clotting activity of factor II (FII:C), factor V (FV:C), factor VII (FVII:C), factor X (FX:C) and fibrinogen. We investigated 157 non-anti-coagulated patients (86 males, 71 females; median age 41 y, range 16-73 ), who had survived ischemic stroke for at least 2 months, and 193 healthy controls with similar age and sex distribution (104 males, 89 females; median age 39 y, range 19-74). Patients showed significantly higher body mass index, as well as significantly higher prevalence of arterial hypertension, smoking and hyperlipidemia. FV:C (p = 0.05), FX:C (p = 0.04) and fibrinogen (p = 0.05) were higher in patients as compared to controls. In a univariate risk analysis FX:C and FV:C were associated with the relative risk for ischemic stroke showing an odds ratio (OR) of up to 2.8 (95% CI: 1.05-7.6) and 3.4 (95%CI: 1.4-7.9), respectively, for levels above 130%. In a multivariate analysis using a logistic regression model including age, sex, arterial hypertension, smoking habit, diabetes, hyperlipidemia, BMI and the coagulation factors, FV:C was still found to significantly (p=0.03) add to the risk of ischemic stroke. An increase of factor FV:C by 10% was associated with an increase in the relative risk of 19% (95% CI.: 2%-38%). In conclusion, we found a high plasma level of FV:C to be a prevalent (FV:C > 130% in 20/157 patients) and independent risk factor for ischemic stroke.

Keywords

Ischemic stroke - risk factors - coagulation - factor V

Full Text

References

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