Autologous platelets as a source of proteins for healing and tissue regeneration

Eduardo Anitua; Isabel Andia; Bruno Ardanza; Paquita Nurden; Alan T. Nurden

doi:10.1160/TH03-07-0440

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 91(01): 4-15
DOI: 10.1160/TH03-07-0440

Review Articles

Schattauer GmbH

Autologous platelets as a source of proteins for healing and tissue regeneration

Eduardo Anitua

¹Biotechnology Institute, Osakidetza, Vitoria, Spain

,

Isabel Andia

²Basque Health Service, Osakidetza, Vitoria, Spain

,

Bruno Ardanza

¹Biotechnology Institute, Osakidetza, Vitoria, Spain

,

Paquita Nurden

³Laboratoire d’Hématologie, Pessac, France

⁴IFR N° 4, Hôpital Cardiologique, Pessac, France

,

Alan T. Nurden

⁴IFR N° 4, Hôpital Cardiologique, Pessac, France

› Author Affiliations

Abstract

Summary

Platelets are known for their role in haemostasis where they help prevent blood loss at sites of vascular injury. To do this, they adhere, aggregate and form a procoagulant surface leading to thrombin generation and fibrin formation. Platelets also release substances that promote tissue repair and influence the reactivity of vascular and other blood cells in angiogenesis and inflammation. They contain storage pools of growth factors including PDGF, TGF-β and VEGF as well as cytokines including proteins such as PF4 and CD40L. Chemokines and newly synthesised active metabolites are also released. The fact that platelets secrete growth factors and active metabolites means that their applied use can have a positive influence in clinical situations requiring rapid healing and tissue regeneration. Their administration in fibrin clot or fibrin glue provides an adhesive support that can confine secretion to a chosen site. Additionally, the presentation of growth factors attached to platelets and/or fibrin may result in enhanced activity over recombinant proteins. Dental implant surgery with guided bone regeneration is one situation where an autologous platelet-rich clot clearly accelerates ossification after tooth extraction and/or around titanium implants. The end result is both marked reductions in the time required for implant stabilisation and an improved success rate. Orthopaedic surgery, muscle and/or tendon repair, reversal of skin ulcers, hole repair in eye surgery and cosmetic surgery are other situations where autologous platelets accelerate healing. Our aim is to review these advances and discuss the ways in which platelets may provide such unexpected beneficial therapeutic effects.

Keywords

Platelets - growth factors - cytokines - healing - dental implant surgery - tissue repair

Full Text

References

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