Thromboprophylaxis in medical patients: the role of low-molecular-weight heparin

Turpie G. G. Alexander; Timothy M. Norris

doi:10.1160/TH03-07-0469

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(01): 3-12
DOI: 10.1160/TH03-07-0469

Review Article

Schattauer GmbH

Thromboprophylaxis in medical patients: the role of low-molecular-weight heparin

Authors

Turpie G. G. Alexander

¹Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada
Timothy M. Norris

²Excerpta Medica Medical Communications, Almere, The Netherlands

Abstract

Summary

Many hospitalised medical patients are at increased risk of venous thromboembolism (VTE). Consensus statements recommend that such patients be assessed for risk of VTE on admission to hospital and receive thromboprophylaxis where appropriate. However, VTE prophylaxis is not widely used in medical patients. One explanation is that assessing medical patients’ risk of VTE is complicated. The risk depends not only on the current illness but also on multiple intrinsic factors, and a variety of strategies for identifying patients who should receive thromboprophylaxis have been suggested. Thromboprophylaxis with unfractionated heparin (UFH) has proved to be effective in reducing the incidence of deep-vein thrombosis and overall mortality in medical patients. Clinical trial evidence, including a meta-analysis, suggests that thromboprophylaxis with low-molecular-weight heparin (LMWH) is at least as effective as with UFH, and also has the advantage of fewer bleeding complications. In particular, two large, randomised clinical trials – Prophylaxis in Medical Patients with Enoxaparin (MEDENOX) and Prospective Evaluation of Dalteparin Efficacy for Prevention of VTE in Immobilized Patients Trial (PREVENT) – showed that thromboprophylaxis with the LMWHs enoxaparin (40 mg s.c. once daily) or dalteparin (5,000 IU once daily) is more effective than placebo and well tolerated in medical patients. In addition, the Thromboembolism-Prevention in Cardiopulmonary Diseases with Enoxaparin (THE-PRINCE) trial showed that enoxaparin treatment was as effective as UFH. These studies provide solid evidence for the widespread use of thromboprophylaxis in medical patients.

Keywords

Venous thromboembolism - deep-vein thrombosis - pulmonary embolism - thromboprophylaxis - low-molecular-weight heparin - medical patients

Full Text

References

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