The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism

Isabel Tirado; José Mateo; José Manuel Soria; Arturo Oliver; Elisabeth Martínez-Sánchez; Cristina Vallvé; Monserrat Borrell; Teresa Urrutia; Jordi Fontcuberta

doi:10.1160/TH04-04-0251

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2005; 93(03): 468-474
DOI: 10.1160/TH04-04-0251

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism

Isabel Tirado

¹Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain

,

José Mateo

¹Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain

,

José Manuel Soria

¹Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain

,

Arturo Oliver

²Fundació Puigvert, Haematology Department, Barcelona, Spain

,

Elisabeth Martínez-Sánchez

¹Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain

,

Cristina Vallvé

¹Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain

,

Monserrat Borrell

¹Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain

,

Teresa Urrutia

¹Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain

,

Jordi Fontcuberta

¹Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain

› Author Affiliations

Abstract

Summary

Factor VIII (FVIII), von Willebrand factor (vWF) and the ABO blood groups have been associated with thrombosis. The ABO locus has functional effects on vWF and FVIII levels and is genetically correlated with FVIII, vWF and thrombosis. We carried out a case-control study to assess the role of FVIII, vWF and ABO types on thrombotic risk. We analyzed 250 patients with venous thrombosis and 250 unrelated controls. FVIII, vWF and other factors related to thrombophilia were measured, ABO groups were analyzed by genotyping. FVIII and vWF were higher in non-O individuals. Group O was more frequent in the controls (44.3% v 23.3%; difference 21.1%; 95% CI: 13.0–29.3%) and Group A in patients (59.2% v. 41.5%; difference 17.7%, 95% CI: 9.1–26.4%). Individuals carrying the A₁ allele had a higher risk of thrombosis (OR 2.6; 95% CI, 1.8–3.8). The risk attributed to vWF disappeared after adjusting for the ABO group. Patients with FVIII above the 90^th percentile had a high thrombotic risk (adjusted OR 3.7; 95%CI, 2.1–6.5), and a high risk of recurrence (OR 2.3; 95%CI: 1.3–4.1). In conclusion, high FVIII levels and non-O blood groups, likely those with the A₁ allele, are independent risk factors for venous thromboembolism and should be considered in evaluating of thrombophilia.

Keywords

Factor VIII - ABO genotypes - von Willebrand factor - venous thrombosis - thrombophilia

Full Text

References

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