Thrombosis and Haemostasis, Table of Contents Thromb Haemost 2005; 93(01): 8-16DOI: 10.1160/TH04-07-0453 Review Article Schattauer GmbH Prevention of cardiovascular disease in type-2 diabetes: How to improve the clinical efficacy of aspirin Virgilio Evangelista 1 Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy , Licia Totani 1 Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy , Serenella Rotondo 1 Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy , Roberto Lorenzet 2 “Antonio Taticchi“ Unit of Cellular and Molecular Biology of Coagulation Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy , Gianni Tognoni 3 Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy , Giorgia De Berardis 3 Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy , Antonio Nicolucci 3 Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy › Author Affiliations Recommend Article Abstract Full Text PDF Download Keywords KeywordsDiabetes/metabolic disorders - inflammatory mediators - platelet pharmacology References References 1 Creager MA, Luscher TF, Cosentino F. et al Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation 2003; 108: 1527-32. 2 UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type-2 diabetes (UKPDS 33) Lancet. 1998; 352: 837-53. 3 Haffner SM. 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