The urokinase plasminogen activator and its receptor

Daniela Alfano; Paola Franco; Immacolata Vocca; Nadia Gambi; Viviana Pisa; Alessandro Mancini; Mario Caputi; Maria Vincenza Carriero; Ingram Iaccarino; Maria Patrizia Stoppelli

doi:10.1160/TH04-09-0592

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2005; 93(02): 205-211
DOI: 10.1160/TH04-09-0592

Theme Issue Article

Schattauer GmbH

The urokinase plasminogen activator and its receptor

Role in cell growth and apoptosis

Authors

Daniela Alfano

¹Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples, Italy
Paola Franco

¹Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples, Italy
Immacolata Vocca

¹Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples, Italy
Nadia Gambi

¹Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples, Italy
Viviana Pisa

¹Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples, Italy
Alessandro Mancini

²Department of Medical-Surgical, Cardiological, Respiratory, and Thoracic Sciences, Second University of Naples, Naples, Italy
Mario Caputi

²Department of Medical-Surgical, Cardiological, Respiratory, and Thoracic Sciences, Second University of Naples, Naples, Italy
Maria Vincenza Carriero

¹Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples, Italy

³National Cancer Institute of Naples, Naples, Italy
Ingram Iaccarino

¹Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples, Italy
Maria Patrizia Stoppelli

¹Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples, Italy

Abstract

Summary

The urinary-type plasminogen activator, or uPA, controls matrix degradation through the conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin generation during cell migration and invasion, under physiological and pathological conditions (such as cancer metastasis).The proteolytic activity of uPA is responsible for the activation or release of several growth factors and modulates the cell survival/apoptosis ratio through the dynamic control of cell-matrix contacts. The urokinase receptor (uPAR), binding to the EGF-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through transmembrane proteins, thus regulating cell migration, adhesion and cytoskeletal status. However, recent evidence highlights an intricate relationship linking the uPA/uPAR system to cell growth and apoptosis.

Keywords

Urokinase - urokinase receptor - cell proliferation - tumour progression - apoptosis

Full Text

References

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