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Thromb Haemost 2007; 97(03): 451-457
DOI: 10.1160/TH06-11-0646
Cardiovascular Biology and Cell Signalling
Schattauer GmbH

The –11377 C>G promoter variant of the adiponectin gene, prevalence of coronary atherosclerosis, and incidence of vascular events in men

Guenter Hoefle   *
1   Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
,
Axel Muendlein   *
2   Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
3   University of Human Sciences, Triesen, Principality of Liechtenstein
,
Christoph H. Saely
1   Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
2   Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
,
Lorenz Risch
1   Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
,
Philipp Rein
1   Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
2   Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
,
Lorena Koch
2   Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
,
Fabian Schmid
2   Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
,
Stefan Aczel
1   Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
2   Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
,
Thomas Marte
1   Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
2   Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
,
Peter Langer
2   Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
,
Heinz Drexel
1   Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
2   Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria
3   University of Human Sciences, Triesen, Principality of Liechtenstein
› Author AffiliationsFinancial support: We received research grants and financial support from: Dr. Egmond Frommelt and the Liechtenstein Global Trust (LGT) Bank Dkfm. Dr. Jodok Simma from the Hypo Bank Vorarlberg, Dr. Guntram Feuerstein and the Fachhochschule Dornbirn and the city of Dornbirn as well as Manfred Rein and Dr. Karlheinz Rüdisser from the Vorarlberger Landesregierung, Franz Rauch and the Vorarlberger Industriellenvereinigung, Dr. Peter Woess and the Vorarlberger Aerztekammer, and Luis Patsch, Director, Vorarlberger Krankenhaus-Betriebsgesellschaft.
Further Information

Publication History

Received 14 November 2006

Accepted after revision 22 February 2006

Publication Date:
15 December 2017 (online)

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Summary

No prospective data demonstrating an association between the –11377 C>G adiponectin gene promoter variant and cardiovascular risk are available. We therefore prospectively evaluated the cardiovascular risk associated with adiponectin gene single nucleotide polmorphisms (SNPs) including SNP –11377 in a consecutive series of men undergoing coronary angiography. We recorded vascular events over four years in 402 men undergoing coronary angiography for the evaluation of coronary artery disease. No significant associations of SNPs +276 G>T and +45 T>G with serum adiponectin, with significant coronary stenoses >50%, or with vascular events were observed. However, for SNP –11377 C>G, serum adiponectin levels significantly decreased (Ptrend = 0.003), and the prevalence of significant coronary stenoses significantly increased from the CC over the GC to the GG genotype (ptrend = 0.004). Prospectively, the risk of vascular events significantly increased from the CC over the CG to the GG genotype of this SNP (adjusted hazard ratios 1.555 [0.957-2.525] and 2.309 [1.067–4.998], respectively; ptrend = 0.014). The –11377 C>G adiponectin gene promoter variant is i) associated with decreased serum adiponectin levels, ii) correlated with the presence of coronary atherosclerosis and iii) significantly predictive of vascular events among men undergoing coronary angiography.

Keywords

Coronary artery disease - angiography - risk factors - cytokines - epidemiology

* Guenter Hoefle and Axel Muendlein contributed equally to this work.


 

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