The –11377 C>G promoter variant of the adiponectin gene, prevalence of coronary atherosclerosis, and incidence of vascular events in men

Guenter Hoefle; Axel Muendlein; Christoph H. Saely; Lorenz Risch; Philipp Rein; Lorena Koch; Fabian Schmid; Stefan Aczel; Thomas Marte; Peter Langer; Heinz Drexel

doi:10.1160/TH06-11-0646

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 97(03): 451-457
DOI: 10.1160/TH06-11-0646

Cardiovascular Biology and Cell Signalling

Schattauer GmbH

The –11377 C>G promoter variant of the adiponectin gene, prevalence of coronary atherosclerosis, and incidence of vascular events in men

Guenter Hoefle^*

¹Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

,

Axel Muendlein^*

²Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

³University of Human Sciences, Triesen, Principality of Liechtenstein

,

Christoph H. Saely

¹Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

²Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

,

Lorenz Risch

¹Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

,

Philipp Rein

¹Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

²Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

,

Lorena Koch

²Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

,

Fabian Schmid

²Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

,

Stefan Aczel

¹Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

²Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

,

Thomas Marte

¹Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

²Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

,

Peter Langer

²Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

,

Heinz Drexel

¹Department of Medicine, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

²Vorarlberg Institute for Vascular Investigation and Treatment, Academic Teaching Hospital Feldkirch, Feldkirch, Austria

³University of Human Sciences, Triesen, Principality of Liechtenstein

› Author Affiliations

Abstract

Summary

No prospective data demonstrating an association between the –11377 C>G adiponectin gene promoter variant and cardiovascular risk are available. We therefore prospectively evaluated the cardiovascular risk associated with adiponectin gene single nucleotide polmorphisms (SNPs) including SNP –11377 in a consecutive series of men undergoing coronary angiography. We recorded vascular events over four years in 402 men undergoing coronary angiography for the evaluation of coronary artery disease. No significant associations of SNPs +276 G>T and +45 T>G with serum adiponectin, with significant coronary stenoses >50%, or with vascular events were observed. However, for SNP –11377 C>G, serum adiponectin levels significantly decreased (P_trend = 0.003), and the prevalence of significant coronary stenoses significantly increased from the CC over the GC to the GG genotype (p_trend = 0.004). Prospectively, the risk of vascular events significantly increased from the CC over the CG to the GG genotype of this SNP (adjusted hazard ratios 1.555 [0.957-2.525] and 2.309 [1.067–4.998], respectively; p_trend = 0.014). The –11377 C>G adiponectin gene promoter variant is i) associated with decreased serum adiponectin levels, ii) correlated with the presence of coronary atherosclerosis and iii) significantly predictive of vascular events among men undergoing coronary angiography.

Keywords

Coronary artery disease - angiography - risk factors - cytokines - epidemiology

Full Text

References

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