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DOI: 10.1160/TH06-11-0646
The –11377 C>G promoter variant of the adiponectin gene, prevalence of coronary atherosclerosis, and incidence of vascular events in men
Financial support: We received research grants and financial support from: Dr. Egmond Frommelt and the Liechtenstein Global Trust (LGT) Bank Dkfm. Dr. Jodok Simma from the Hypo Bank Vorarlberg, Dr. Guntram Feuerstein and the Fachhochschule Dornbirn and the city of Dornbirn as well as Manfred Rein and Dr. Karlheinz Rüdisser from the Vorarlberger Landesregierung, Franz Rauch and the Vorarlberger Industriellenvereinigung, Dr. Peter Woess and the Vorarlberger Aerztekammer, and Luis Patsch, Director, Vorarlberger Krankenhaus-Betriebsgesellschaft.Publication History
Received
14 November 2006
Accepted after revision
22 February 2006
Publication Date:
15 December 2017 (online)


Summary
No prospective data demonstrating an association between the –11377 C>G adiponectin gene promoter variant and cardiovascular risk are available. We therefore prospectively evaluated the cardiovascular risk associated with adiponectin gene single nucleotide polmorphisms (SNPs) including SNP –11377 in a consecutive series of men undergoing coronary angiography. We recorded vascular events over four years in 402 men undergoing coronary angiography for the evaluation of coronary artery disease. No significant associations of SNPs +276 G>T and +45 T>G with serum adiponectin, with significant coronary stenoses >50%, or with vascular events were observed. However, for SNP –11377 C>G, serum adiponectin levels significantly decreased (Ptrend = 0.003), and the prevalence of significant coronary stenoses significantly increased from the CC over the GC to the GG genotype (ptrend = 0.004). Prospectively, the risk of vascular events significantly increased from the CC over the CG to the GG genotype of this SNP (adjusted hazard ratios 1.555 [0.957-2.525] and 2.309 [1.067–4.998], respectively; ptrend = 0.014). The –11377 C>G adiponectin gene promoter variant is i) associated with decreased serum adiponectin levels, ii) correlated with the presence of coronary atherosclerosis and iii) significantly predictive of vascular events among men undergoing coronary angiography.
* Guenter Hoefle and Axel Muendlein contributed equally to this work.