Neutrophil activation via β2 integrins (CD11/CD18): Molecular mechanisms and clinical implications

Jürgen Schymeinsky; Attila Mócsai; Barbara Walzog

doi:10.1160/TH07-02-0156

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(02): 262-273
DOI: 10.1160/TH07-02-0156

Theme Issue Article

Schattauer GmbH

Neutrophil activation via β₂ integrins (CD11/CD18): Molecular mechanisms and clinical implications

Jürgen Schymeinsky

¹Dept. of Physiology, Ludwig-Maximilians-University Munich, Munich, Germany

,

Attila Mócsai

²Dept. of Physiology, Semmelweis University School of Medicine, Budapest, Hungary

,

Barbara Walzog

¹Dept. of Physiology, Ludwig-Maximilians-University Munich, Munich, Germany

› Author Affiliations

Abstract

Summary

Polymorphonuclear neutrophils (PMN) are key components of the innate immunity and their efficient recruitment to the sites of lesion is a prerequisite for acute inflammation. Signaling via adhesion molecules of the β₂ integrin family (CD11/CD18) plays an essential role for PMN recruitment and activation during inflammation. In this review, we will focus on the non-receptor tyrosine kinase Syk, an important downstream signaling component of β₂ integrins that is required for the control of different PMN functions including adhesion,migration and phagocytosis. The exploration of β₂ integrin-mediated Syk activation provided not only novel insights into the control of PMN functions but also led to the identification of Syk as a new molecular target for therapeutic intervention during inflammatory diseases.

Keywords

Integrins - inflammation - leukocyte trafficking / recruitment - signal transduction

Full Text

References

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