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Thromb Haemost 2007; 98(02): 327-332
DOI: 10.1160/TH07-03-0206
Review Article
Schattauer GmbH

Regulation of vascular endothelial permeability by junctional adhesion molecules (JAM)

Valeria V. Orlova
1   Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
,
Triantafyllos Chavakis
1   Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
› Author Affiliations
Further Information

Publication History

Received 19 March 2007

Accepted after revision 09 May 2007

Publication Date:
28 November 2017 (online)

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Summary

The vascular endothelium forms a barrier between the circulation and the interstitium, and changes in vascular permeability are very important during vascular repair and inflammatory conditions. The regulation of the endothelial barrier depends on actomyosin- related cell contractility as well as the integrity of cellcell junctions, such as tight and adherens junctions.The present review will introduce the basic pathways involved in the regulation of the endothelial barrier as well as important participating signaling players, such as the small GTPases RhoA, Rac and Rap1. In this context, we will attempt to analyze and interpret the recent evidence pointing to the role of the family of junctional adhesion molecules (JAMs) in modulating the pathways involved in the regulation of the endothelial barrier.

Keywords

Adhesion molecules - cadherins - endothelial cells - inflammation - GTPases
 

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