Thrombosis and Haemostasis, Table of Contents Thromb Haemost 2007; 98(06): 1232-1236DOI: 10.1160/TH07-05-0376 Blood Coagulation, Fibrinolysis and Cellular Haemostasis Schattauer GmbH Prediction of recurrent venous thromboembolism by measuring ProC Global Authors Author Affiliations Sabine Eichinger 1 Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria Gregor Hron 1 Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria Mirko Hirschl 2 Department of Angiology, Hanuschkrankenhaus, Vienna, Austria Christine Bialonczyk 3 Department of Dermatology, Wilhelminenspital, Vienna, Austria Erich Minar 4 Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria Marietta Kollars 1 Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria Paul A. Kyrle 1 Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria Recommend Article Abstract Buy Article(opens in new window) Summary In patients with venous thromboembolism (VTE) a laboratory assay that globally measures the overall thrombophilic tendency is not available. We hypothesized that determination of ProC® Global, a plasma assay which tests the global function of the protein C pathway, could be used to stratify patients according to their risk of recurrent VTE. We prospectively followed 774 patients with first spontaneous VTE for a mean time of 52 months. ProC Global normalized ratio (NR) was measured in plasma by use of a commercially available assay based on activated partial thromboplastin time. Ninety-eight of the 774 patients had recurrent VTE. Patients with ProC Global NR ≥ 0.75 had a relative risk of recurrence of 0.59 (95% CI 0.40–0.87) as compared with those with lower ratio. After four years, cumulative probability of recurrence was 8.6% in patients with ProC Global NR ≥ 0.75 and 17.4% in patients with a lower ratio (p=0.006). Patients with a high ProC Global NR have a low risk of recurrent VTE. ProC Global NR can be used to stratify patients with a first unprovoked VTE according to their risk of recurrence. Keywords KeywordsVenous thrombosis - recurrence - ProC Global Full Text References References 1 Mannucci PM. Laboratory detection of inherited thrombophilia: a historical perspective. Semin Thromb Hemost 2005; 31: 5-10. 2 Palareti G, Legnani C, Cosmi B. et al. Risk of venous thromboembolism recurrence: high negative predictive value of D-dimer performed after oral anticoagulation is stopped. Thromb Haemost 2002; 87: 7-12. 3 Eichinger S, Minar E, Bialonczyk C. et al. D-dimer levels and risk of recurrent venous thromboembolism. J Am Med Assoc 2003; 290: 1071-1074. 4 Tripodi A, Chantarangkul V, Martinelli I. et al. 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