Early postoperative obstructive prosthetic mitral valve thrombosis in a patient double heterozygous for factor V Leiden and prothrombin G20210A mutation

Stefano De Paulis; Elena Rossi; Roberto Zamparelli; Andrea Scapigliati; Michele Corrado; Valerio De Stefano

doi:10.1160/TH07-11-0687

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2008; 99(02): 441-442
DOI: 10.1160/TH07-11-0687

Case Report

Schattauer GmbH

Early postoperative obstructive prosthetic mitral valve thrombosis in a patient double heterozygous for factor V Leiden and prothrombin G20210A mutation

Stefano De Paulis

¹Department of Cardiovascular Medicine

,

Elena Rossi

²Institute of Hematology, Catholic University, Rome, Italy

,

Roberto Zamparelli

¹Department of Cardiovascular Medicine

,

Andrea Scapigliati

¹Department of Cardiovascular Medicine

,

Michele Corrado

¹Department of Cardiovascular Medicine

,

Valerio De Stefano

²Institute of Hematology, Catholic University, Rome, Italy

› Author Affiliations

Abstract

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References

References
1 Dürrleman N, Pellerin M, Bouchard D. et al. Prosthetic valve thrombosis: twenty-year experience at the Montreal Heart Institute. J Thorac Cardiovasc Surg 2004; 127: 1388-1392.
2 Roudaut R, Serri K, Lafitte S. Thrombosis of prosthetic heart valves: diagnosis and therapeutic considerations. Heart 2007; 93: 137-142.
3 Ames PR, Ciampa A, Margaglione M. et al. Bleeding and re-thrombosis in primary antiphospholipid syndrome on oral anticoagulation: an 8-year longitudinal comparison with mitral valve replacement and inherited thrombophilia. Thromb Haemost 2005; 93: 694-699.
4 Rizzoli G, Guglielmi C, Toscano G. et al. Reoperations for acute prosthetic thrombosis and pannus: an assessment of rates, relationship and risk. Eur J Cardiothorac Surg 1999; 16: 74-80.
5 Gencbay M, Turan F, Degertekin M. et al. High prevalence of hypercoagulable states in patient with recurrent thrombosis of mechanical heart valves. J Heart Valve Dis 1998; 7: 601-609.
6 Mammo L, Saour JN. Lack of association between factor V Leiden and thromboembolism in patients with prosthetic heart valves. Blood Coagul Fibrinolysis 1999; 10: 141-144.
7 Pegoraro C, Biasiolo A, Iliceto S. et al. Mechanical prosthetic heart valve thrombosis despite optimal anticoagulation in a patient with congenital thrombophilia (factor V Leiden). Clin Appl Thromb Hemost 2003; 9: 89-90.
8 De Stefano V, Rossi E, Paciaroni K. et al. Screening for inherited thrombophilia: indications and therapeutic implications. Haematologica 2002; 87: 1095-1108.
9 Emmerich J, Rosendaal FR, Cattaneo M. et al. Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism— pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. Thromb Haemost 2001; 86: 809-816.
10 De Stefano V, Martinelli I, Mannucci PM. et al. The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation. N Engl J Med 1999; 341: 801-806.
11 Fanashawe MP, Shore-Lesserson L, Reich DL. Two cases of fatal thrombosis after aminocaproic acid therapy and deep hypothermic circulatory arrest. Anesthesiology 2001; 95: 1525-1527.
12 Shore-Lesserson L, Reich DL. A case of severe diffuse venous thromboembolism associated with aprotinin and hypothermic circulatory arrest in a cardiac surgical patient with factor V Leiden. Anesthesiology 2006; 105: 219-221.