The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury

Sabine Steffens; Fabrizio Montecucco; François Mach

doi:10.1160/TH08-12-0837

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2009; 102(02): 240-247
DOI: 10.1160/TH08-12-0837

Theme Issue Article

Schattauer GmbH

The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury

Sabine Steffens

¹Division of Cardiology, Foundation for Medical Researches, University Hospital, Geneva, Switzerland

,

Fabrizio Montecucco

¹Division of Cardiology, Foundation for Medical Researches, University Hospital, Geneva, Switzerland

,

François Mach

¹Division of Cardiology, Foundation for Medical Researches, University Hospital, Geneva, Switzerland

› Author Affiliations

Abstract

Summary

Acute myocardial infarction is the leading cause of morbidity and mortality in the adult population of developed and developing nations. Although the prompt restoration of antegrade blood flow in the infarct-related coronary artery is the mean therapy for improving survival, reperfusion itself may cause damage to ischaemic myocardial tissue. This event is well known as “reperfusion injury”. Crucial mediators for cardiac damage in the reperfusion phases are oxidative stress, inflammation and leukocyte infiltration. Already approved and novel therapies might directly reduce these inflammatory processes. Treatments modulating chemokine secretion and activity should be considered as very promising approaches to reduce myocardial reperfusion injury.

Keywords

Acute myocardial infarction - chemokines - inflammation

Full Text

References

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