Novel aspects in the regulation of the leukocyte adhesion cascade

Emmanouil Chavakis; Eun Young Choi; Triantafyllos Chavakis

doi:10.1160/TH08-12-0844

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2009; 102(02): 191-197
DOI: 10.1160/TH08-12-0844

Theme Issue Article

Schattauer GmbH

Novel aspects in the regulation of the leukocyte adhesion cascade

Emmanouil Chavakis

¹Institute of Cardiovascular Regeneration, Dept. of Internal Medicine III, J.W. Goethe University Frankfurt, Frankfurt, Germany

,

Eun Young Choi

²Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland, USA

,

Triantafyllos Chavakis

²Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland, USA

› Institutsangaben

Abstract

Summary

Leukocyte recruitment plays a major role in the immune response to infectious pathogens and during inflammatory and autoimmune disorders. The process of leukocyte extravasation from the blood into the inflamed tissue requires a complex cascade of adhesive events between the leukocytes and the endothelium including leukocyte rolling, adhesion and transendothelial migration. Leukocyte-endothelial interactions are mediated by tightly regulated binding interactions between adhesion receptors on both cells. In this regard, leukocyte adhesion onto the endothelium is governed by leukocyte integrins and their endothelial counter-receptors of the immunoglobulin superfamily. The present review will focus on novel aspects with respect to the modulation of the leukocyte adhesion cascade.

Keywords

Adhesion receptors - cell-cell interactions - endothelial cells - inflammation - integrins

Volltext

Referenzen

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