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Thromb Haemost 2009; 102(03): 437-453
DOI: 10.1160/TH09-04-0221
Review Article
Schattauer GmbH

Molecular diversity of anticoagulants from haematophagous animals

Cho Yeow Koh
1   Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
,
R. Manjunatha Kini
1   Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
2   Department of Biochemistry, Virginia Commonwealth University Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
› Author Affiliations
Further Information

Publication History

Received: 02 April 2009

Accepted after minor revision: 11 June 2009

Publication Date:
22 November 2017 (online)

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Summary

To obtain blood meals, haematophagous animals are armed with potent pharmacological molecules to overcome several of their hosts’ response systems. Among them, a large number of exogenous anticoagulants which target the haemostatic system have been identified and characterised. Studies on these anticoagulants have expanded our knowledge on the blood coagulation system, and provided a valuable source of antithrombotic therapeutic agents. Advances in genomic, transcriptomic, structural and proteomic tools greatly accelerated the discovery and analysis of the exogenous anticoagulants in recent years. The molecular diversity observed in these molecules is huge and is constantly expanding. In this review, we will provide an overview on the structure, function and mechanism of the exogenous anticoagulants from haematophagous animals and rationalise their molecular diversity.

Keywords

Anticoagulants - haematophagous animals - structure-function relationships - exogenous factors - molecular diversity
 

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