The role of thrombin and protease-activated receptors in pain mechanisms

Paul S. García; Amitabh Gulati; Jerrold H. Levy

doi:10.1160/TH09-12-0848

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2010; 103(06): 1145-1151
DOI: 10.1160/TH09-12-0848

Review Article

Schattauer GmbH

The role of thrombin and protease-activated receptors in pain mechanisms

Paul S. García

¹Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA

,

Amitabh Gulati

¹Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA

,

Jerrold H. Levy

¹Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA

› Author Affiliations

Abstract

Summary

As our knowledge of the mechanisms underlying the sensation of pain continues to expand, researchers are constantly searching for novel therapeutic targets. One such novel pain pathway involves thrombin and its associated protease-activated receptor (PAR). Besides its traditional role in haemostasis, thrombin has multiple roles in both the central and peripheral nervous system including activation of microglia, regulation of neuronal death and neurite outgrowth, and influencing the transmission of pain signals in the nociceptive circuitry. Eventually therapeutic modalities directed at these targets could provide novel therapeutic approaches for treating chronic pain. The thrombin-associ-ated PARs also have roles in inflammation, neurodevelopment, and conducting pain, both in conjunction with thrombin and independently. Recent laboratory evidence suggests that the PARs can attenuate pain mediated by the enteric nervous system in animal models (for example in pancreatitis and colitis). This review highlights several pathways in the mediation of pain sensation that can be influenced by thrombin.

Keywords

Thrombin - protease activated receptor - pain - hemostasis - coagulation - inflammation

Full Text

References

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