Emotional states and future risk of venous thromboembolism

Kristin F. Enga; Sigrid K. Brækkan; Ida J. Hansen-Krone; John-Bjarne Hansen

doi:10.1160/TH11-09-0667

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2012; 107(03): 485-493
DOI: 10.1160/TH11-09-0667

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Emotional states and future risk of venous thromboembolism

The Tromsø Study

Kristin F. Enga

¹Hematological research group (HERG), Department of Clinical Medicine, University of Tromsø, Norway

,

Sigrid K. Brækkan

¹Hematological research group (HERG), Department of Clinical Medicine, University of Tromsø, Norway

²Division of Internal Medicine, University Hospital of North Norway, Tr omsø, Norway

,

Ida J. Hansen-Krone

¹Hematological research group (HERG), Department of Clinical Medicine, University of Tromsø, Norway

,

John-Bjarne Hansen

¹Hematological research group (HERG), Department of Clinical Medicine, University of Tromsø, Norway

²Division of Internal Medicine, University Hospital of North Norway, Tr omsø, Norway

› Author Affiliations

Abstract

Summary

Emotional states of depression and loneliness are reported to be associated with higher risk and optimism with lower risk of arterial cardiovascular disease (CVD) and death. The relation between emotional states and risk of venous thromboembolism (VTE) has not been explored previously. We aimed to investigate the associations between self-reported emotional states and risk of incident VTE in a population-based, prospective study. The frequency of feeling depressed, lonely and happy/optimistic were registered by self-administered questionnaires, along with major co-morbidities and lifestyle habits, in 25,964 subjects aged 25–96 years, enrolled in the Tromsø Study in 1994–1995. Incident VTE-events were registered from the date of inclusion until September 1, 2007. There were 440 incident VTE-events during a median of 12.4 years of follow-up. Subjects who often felt depressed had 1.6-fold (95% CI:1.02–2.50) higher risk of VTE compared to those not depressed in analyses adjusted for other risk factors (age, sex , body mass index, oes-trogens), lifestyle (smoking, alcohol consumption, educational level) and co-morbidities (diabetes, CVD, and cancer). Often feeling lonely was not associated with VTE. However, the incidence rate of VTE in subjects who concurrently felt often lonely and depressed was higher than for depression alone (age-and sex-adjusted incidence rate: 3.27 vs. 2.21). Oppositely, subjects who often felt happy/optimistic had 40% reduced risk of VTE (HR 0.60, 95% CI: 0.41–0.87). Our findings suggest that self-reported emotional states are associated with risk of VTE. Depressive feelings were associated with increased risk, while happiness/ optimism was associated with reduced risk of VTE.

Keywords

Depression - emotional states - happiness - psychosocial factor - venous thromboembolism

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References

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