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Thromb Haemost 2012; 108(04): 592-598
DOI: 10.1160/TH12-02-0097
DOI: 10.1160/TH12-02-0097
Theme Issue Article
Analytical challenges and technical limitations in assessing circulating MiRNAs
Further Information
Publication History
Received:
17 February 2012
Accepted after minor revision:
17 April 2012
Publication Date:
29 November 2017 (online)
Summary
MiRNAs are emerging as promising biomarkers in cardiovascular diseases and may constitute a novel mechanism of intercellular communication. Accurate quantification of circulating miRNAs is essential. A variety of technological approaches and platforms have been developed with increased sensitivity and specificity for the detection and quantification of circulating miRNAs. In this review, we focus on the technical aspects and discuss the analytical challenges in profiling circulating miRNAs.
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