Thrombosis and Haemostasis, Table of Contents Thromb Haemost 2012; 108(01): 1-2DOI: 10.1160/TH12-05-0312 Invited Editorial Focus Schattauer GmbH Propanolol and angiogenesis inhibition in hereditary haemorrhagic telangiectasia Authors Author Affiliations Georg Breier Institute of Pathology, University Clinic Dresden, Dresden, Germany Recommend Article Abstract Buy Article(opens in new window) Full Text References References 1 Fernández-L A, Sanz-Rodriguez F, Blanco FJ. et al. Hereditary hemorrhagic telangiectasia, a vascular dysplasia affecting the TGF-beta signaling pathway. Clin Med Res 2006; 04: 66-78. 2 Shovlin CL. Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment. Blood Rev 2010; 24: 203-219. 3 Mahmoud M, Upton PD, Arthur HM. Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease. Biochem Soc Trans 2011; 39: 1659-1666. 4 en Dijke P, Goumans MJ, Pardali E. Endoglin in angiogenesis and vascular diseases. Angiogenesis 2008; 11: 79-89. 5 Albiñana V, Bernabeu-Herrero ME, Zarrabeitia R. et al. Estrogen therapy for hereditary haemorrhagic telangiectasia (HHT): Effects of raloxifene, on Endoglin and ALK1 expression in endothelial cells. Thromb Haemost 2010; 103: 525-534. 6 Bose P, Holter JL, Selby GB. Bevacizumab in hereditary hemorrhagic telangiectasia. N Engl J Med 2009; 360: 2143-2144. 7 Kabbinavar F, Hurwitz HI, Fehrenbacher L. et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21: 60-65. 8 Lebrin F, Srun S, Raymond K. et al. Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat Med 2010; 16: 420-428. 9 Kurstin R. Using thalidomide in a patient with epithelioid leiomyosarcoma and Osler-Weber-Rendu disease. Oncology 2002; 16: 21-24. 10 Albiñana V, Recio-Poveda L, Zarrabeitia R. et al. Propranolol as antiangiogenic candidate for the therapy of hereditary haemorrhagic telangiectasia. Thromb Haemost 2012; 108: 41-53. 11 Lamy S, Lachambre M P, Lord-Dufour S. et al. Propranolol suppresses angiogenesis in vitro: inhibition of proliferation, migration, and differentiation of endothelial cells. Vascul Pharmacol 2010; 53: 200-208. 12 Léauté-Labrèze C, Dumas de la, Roque E, Hubiche T. et al. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008; 358: 2649-2651. 13 Mazzone M, Dettori D, Leite de Oliveira R. et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009; 136: 839-851.
