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Thromb Haemost 2013; 109(04): 696-705
DOI: 10.1160/TH12-09-0654
Endothelium and Vascular Development
Schattauer GmbH

Disruption of components of vascular endothelial growth factor angiogenic signalling system in metabolic syndrome

Findings from a study conducted in rural Bangladeshi women
Subrina Jesmin
1   Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh
2   Graduate School of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
3   National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
,
Shamima Akter
1   Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh
3   National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
,
Md. Mizanur Rahman
4   Department of Global Health Policy, University of Tokyo, Tokyo, Japan
,
Md. Majedul Islam
1   Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh
3   National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
,
A. M. Shahidul Islam
1   Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh
3   National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
,
Sayeeda N. Sultana
1   Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh
3   National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
,
Chishimba N. Mowa
1   Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh
,
Naoto Yamaguchi
1   Health & Disease Research Center for Rural Peoples (HDRCRP), Mohammadpur, Dhaka, Bangladesh
,
Osamu Okazaki
3   National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
,
Kawano Satoru
2   Graduate School of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
,
Sosuke Kimura
3   National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
,
Michiaki Hiroe
3   National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
,
Taro Mizutani
2   Graduate School of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
,
Masao Moroi
3   National Center for Global Health and Medicine (NCGM), Shinjuku-ku, Tokyo, Japan
› Author Affiliations Financial support: This work was supported in part by a Grant-in-Aid for Scientific Research (overseas academic) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (22406025, 23406037, 23406029, 24406026) and Japan Society for the promotion of Science. A part of this work has also been supported by research grant from Uehara Memorial Foundation (Japan).
Further Information

Publication History

Received: 07 September 2012

Accepted: 09 January 2013

Publication Date:
22 November 2017 (online)

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Summary

Metabolic syndrome (MetS) is associated with impaired angiogenesis, a process that is chiefly regulated by vascular endothelial growth factor (VEGF) upon binding to its specific receptors, VEGF-R1 and VEGF-R2. The purpose of the present study was to assess trends or patterns in plasma levels of VEGF and its soluble receptors in subjects with (MetS) or without (non-MetS) MetS; and further examine their association with clinical or metabolic parameters using a subpopu-lation of South Asian country. A total of 1,802 rural Bangladeshi women aged ≥15 years were studied using a population-based cross-sectional survey. Plasma levels of VEGF were found to be significantly increased (MetS vs. non-MetS: 483.9 vs. 386.9, p<0.001), whereas, the soluble forms of VEGF receptors, sVEGF-R1 and sVEGF-R2, were significantly decreased in subjects with Mets (sVEGF-R1, MetS vs. non-MetS: 512.5 vs. 631.3, p<0.001; sVEGF-R2, MetS vs. non-MetS: 9,302.8 vs. 9,787.4, p=0.004). After adjustment for age and all potential variables, multiple regression analysis revealed that plasma levels of VEGF had significant positive association with blood glucose (p = 0.019) and body mass index (p = 0.007). We also found that mean plasma levels of VEGF increased in direct proportion to levels of MetS components. The present study is the first ever to demonstrate a positive association between trends in levels of plasma VEGF and MetS using a large sample size from South Asia. The association between plasma VEGF and MetS needs further investigations in order to clearly decipher the clinical predictive value and accuracy of plasma VEGF in MetS.

Keywords

Metabolic syndrome - vascular endothelial growth factor - rural Bangladeshi women - South Asian
 

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