Prostate-specific kallikrein-related peptidases and their relation to prostate cancer biology and detection

Daniel L. J. Thorek; Michael J. Evans; Sigrid V. Carlsson; David Ulmert; Hans Lilja

doi:10.1160/TH13-04-0275

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 110(03): 484-492
DOI: 10.1160/TH13-04-0275

Theme Issue Article

Schattauer GmbH

Prostate-specific kallikrein-related peptidases and their relation to prostate cancer biology and detection

Established relevance and emerging roles

Daniel L. J. Thorek

¹Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA;

,

Michael J. Evans

²Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

,

Sigrid V. Carlsson

³Department of Urology, Sahlgrenska Academy at University of Göteborg, Göteborg, Sweden

⁴Department of Surgery (Urology Service), Memorial Sloan-Kettering Cancer Center, New York, New York, USA

,

David Ulmert

⁴Department of Surgery (Urology Service), Memorial Sloan-Kettering Cancer Center, New York, New York, USA

,

Hans Lilja

⁴Department of Surgery (Urology Service), Memorial Sloan-Kettering Cancer Center, New York, New York, USA

⁵Departments of Laboratory Medicine and Medicine (GU Oncology Service), Memorial Sloan-Kettering Cancer Center, New York, New York, USA

⁶Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden

⁷Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK;

⁸Institute of Biomedical Technology, University of Tampere, Tampere, Finland

› Author Affiliations

Abstract

summary

Kallikreins are a family of serine proteases with a range of tissue-specific and essential proteolytic functions. Among the best studied are the prostate tissue-specific KLK2 and KLK3 genes and their secreted protease products, human kallikrein 2, hk2, and prostate-specific antigen (PSA). Members of the so-called classic kallikreins, these highly active trypsin-like serine proteases play established roles in human reproduction. Both hK2 and PSA expression is regulated by the androgen receptor which has a fundamental role in prostate tissue development and progression of disease. This feature, combined with the ability to sensitively detect different forms of these proteins in blood and biopsies, result in a crucially important biomarker for the presence and recurrence of cancer. Emerging evidence has begun to suggest a role for these kallikreins in critical vascular events. This review discusses the established and developing biological roles of hK2 and PSA, as well as the historical and advanced use of their detection to accurately and non-invasively detect and guide treatment of prostatic disease.

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References

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