Aspirin and P2Y12 Inhibitors in platelet-mediated activation of neutrophils and monocytes

Waltraud C. Schrottmaier; Julia B. Kral; Sigrun Badrnya; Alice Assinger

doi:10.1160/TH14-11-0943

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2015; 114(03): 478-789
DOI: 10.1160/TH14-11-0943

Theme Issue Article

Schattauer GmbH

Aspirin and P2Y₁₂ Inhibitors in platelet-mediated activation of neutrophils and monocytes

Waltraud C. Schrottmaier

¹Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria

,

Julia B. Kral

¹Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria

,

Sigrun Badrnya

¹Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria

,

Alice Assinger

¹Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria

²Centre for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden

› Author Affiliations

Abstract

Summary

Platelets are key players in haemostasis and represent a pivotal link between inflammation, immunity and atherogenesis. Depending on the (patho)physiological environment platelets modulate various leukocyte functions via release of inflammatory mediators and direct cell-cell interactions. Elevated levels of circulating platelet-leukocyte aggregates are found in patients suffering from several thrombotic or inflammatory conditions. Platelet-monocyte and platelet-neutrophil interaction can trigger pro- and anti-inflammatory responses and modulate effector functions of all leukocyte subpopulations. These platelet-mediated immune responses have implications for the progression of cardiovascular diseases and also play a crucial role during infections, cancer, transplantations and other inflammatory diseases of several organs. Antiplatelet therapy including the COX inhibitor aspirin and/or ADP receptor P2Y₁₂ inhibitors such as clopidogrel, prasugrel and ticagrelor are the therapy of choice for various cardiovascular complications. Both aspirin and P2Y₁₂ inhibitors attenuate platelet-leukocyte interactions, thereby also modulating immune responses. This may have beneficial effects in some pathological conditions, while it might be detrimental in others. This review aims to summarise the current knowledge on platelet-leukocyte interactions and the impact of aspirin and P2Y₁₂ inhibition on platelet-mediated immune responses and to give an overview on the effects of antiplatelet therapy on platelet-leukocyte interplay in various diseases.

Keywords

Platelet-leukocyte interaction - platelet immunology - inflammation - antiplatelet agents - aspirin - P2Y₁₂ inhibitors

Full Text

References

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