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Thromb Haemost 2016; 115(06): 1220-1228
DOI: 10.1160/TH15-10-0775
Stroke, Systemic or Venous Thromboembolism
Schattauer GmbH

Use of statins and reduced risk of recurrence of VTE in an older population

A population-based cohort study
Vicky Tagalakis
1   Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada
2   Department of Medicine, McGill University, Montréal, Québec, Canada
,
Maria Eberg
1   Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada
,
Susan Kahn
1   Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada
2   Department of Medicine, McGill University, Montréal, Québec, Canada
,
Laurent Azoulay
1   Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada
3   Department of Oncology, McGill University, Montréal, Québec, Canada
› Author Affiliations
Further Information

Publication History

Received: 05 October 2015

Accepted after major revision: 16 January 2016

Publication Date:
27 November 2017 (online)

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Summary

We aimed to determine whether statin use is associated with a decreased risk of recurrent venous thromboembolism (VTE) in older patients. We used a pre-assembled cohort of patients at least 65 years of age diagnosed with incident VTE between January 1, 1994 and December 31, 2004 in the province of Québec, Canada and followed until December 31, 2005. Time-dependent Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) of recurrent VTE associated with current and past use of statins, compared with non-use. The cohort included 25,681 patients with incident VTE. During a mean follow-up of 3.0 years, there were 2343 recurrent VTE events (rate: 3.1 per 100 personyears). Compared with non-use, current use of statins was associated with a decreased risk of VTE recurrence (rates: 1.55 vs 3.47 per 100 per year, respectively; HR: 0.74, 95 % CI: 0.61–0.89), while no association was observed with past use (HR: 0.98, 95 % CI: 0.76–1.25). In a secondary analysis, longer durations of statin use were associated with greater risk reductions (0–6 months, HR 0.82, 95 % CI: 0.67–1.01; 6–12 months, HR 0.62, 95 % CI: 0.43–0.90; ≥ 12 months, HR: 0.50, 95 % CI: 0.33–0.74; p-value for trend ≤ 0.001). The use of statin was associated with a decreased risk of recurrent VTE in older patients. This study supports the need for randomised controlled trials to assess the efficacy and safety of statins in the long-term treatment of VTE.

Keywords

Deep-vein thrombosis - elderly - pulmonary embolism - statins - venous thromboembolism

* This work was carried out at the Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal. Presented in oral abstract form at the European Society of Cardiology Congress, Barcelona, Spain. August 2014.


 

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