Download PDF
Thromb Haemost 2017; 117(01): 201-203
DOI: 10.1160/TH16-08-0594
Letters to the Editor
Schattauer GmbH

Impact of chronic kidney disease on platelet P2Y12 receptor signalling in patients with type 2 diabetes mellitus

Lydia R. Engwenyu   *
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Francesco Franchi   *
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Fabiana Rollini
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Jung Rae Cho
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Christopher DeGroat
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Mona Bhatti
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Zeina Alobaidi
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Elisabetta Ferrante
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Joseph A. Jakubowski
2   Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
,
Atsuhiro Sugidachi
3   Daiichi Sankyo Co., Ltd., Tokyo, Japan
,
Martin M. Zenni
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Theodore A. Bass
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Dominick J. Angiolillo
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
› Author AffiliationsThis work was supported by an Institutional Grant of the University of Florida College of Medicine-Jacksonville. Clopidogrel active metabolite was provided by Daiichi Sankyo Co. Ltd (Tokyo, Japan).
Further Information

Publication History

Received: 01 August 2016

Accepted after major revision: 30 September 2016

Publication Date:
01 December 2017 (online)

Also available at
    Permissions and Reprints

Supplementary Material to this article is available online at www.thrombosis-online.com.

* * Equally contributed as first authors.


 

  • References

  • 1 Haffner SM, Lehto S, Rönnemaa T. et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998; 339: 229-234.
    CrossrefPubMedSearch in Google Scholar
  • 2 Best PJ, Lennon R, Ting HH. et al. The impact of renal insufficiency on clinical outcomes in patients undergoing percutaneous coronary interventions. J Am Coll Cardiol 2002; 39: 1113-1119.
    CrossrefPubMedSearch in Google Scholar
  • 3 Franchi F, Angiolillo DJ, Ghukasyan T. et al. Impact of diabetes mellitus and chronic kidney disease on cardiovascular outcomes and platelet P2Y12 receptor antagonist effects in patients with acute coronary syndromes: insights from the PLATO trial. Eur Heart J 2016; 37: 1224. (Abstract)
    PubMedSearch in Google Scholar
  • 4 Rollini F, Franchi F, Muñiz-Lozano A, Angiolillo DJ. Platelet function profiles in patients with diabetes mellitus. J Cardiovasc Transl Res 2013; 06: 329-345.
    CrossrefPubMedSearch in Google Scholar
  • 5 Franchi F, Rollini F, Angiolillo DJ. Defining the link between chronic kidney disease, high platelet reactivity, and clinical outcomes in clopidogrel-treated patients undergoing percutaneous coronary intervention. Circ Cardiovasc Interv 2015; 08: e002760.
    CrossrefPubMedSearch in Google Scholar
  • 6 Fan W, Plent S, Prats J, Deliargyris EN. Trends in P2Y12 inhibitor use in patients referred for invasive evaluation of coronary artery disease in contemporary US practice. Am J Cardiol 2016; 117: 1439-1443.
    CrossrefPubMedSearch in Google Scholar
  • 7 Angiolillo DJ, Jakubowski JA, Ferreiro JL. et al. Impaired responsiveness to the platelet P2Y12 receptor antagonist clopidogrel in patients with type 2 diabetes and coronary artery disease. J Am Coll Cardiol 2014; 64: 1005-1014.
    CrossrefPubMedSearch in Google Scholar
  • 8 Angiolillo DJ, Bernardo E, Capodanno D. et al. Impact of chronic kidney disease on platelet function profiles in diabetes mellitus patients with coronary artery disease taking dual antiplatelet therapy. J Am Coll Cardiol 2010; 55: 1139-1146.
    CrossrefPubMedSearch in Google Scholar
  • 9 Baber U, Bander J, Karajgikar R. et al. Combined and independent impact of diabetes mellitus and chronic kidney disease on residual platelet reactivity. Thromb Haemost 2013; 110: 118-123.
    Thieme ConnectPubMedSearch in Google Scholar
  • 10 Tello-Montoliu A, Ferreiro JL, Kodali MK. et al. Impact of renal function on clopidogrel-induced antiplatelet effects in coronary artery disease patients without diabetes mellitus. J Thromb Thrombolysis 2013; 36: 14-17.
    CrossrefPubMedSearch in Google Scholar
  • 11 Mangiacapra F, Cavallari I, Barbato E. et al. Impact of chronic kidney disease on platelet reactivity and outcomes of patients receiving clopidogrel and undergoing percutaneous coronary intervention. Am J Cardiol 2014; 113: 1124-1129.
    CrossrefPubMedSearch in Google Scholar
  • 12 Baber U, Mehran R, Kirtane AJ. et al. Prevalence and impact of high platelet reactivity in chronic kidney disease: results from the Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents Registry. Circ Cardiovasc Interv 2015; 08: e001683.
    CrossrefPubMedSearch in Google Scholar
  • 13 American Diabetes Association. Classification and Diagnosis of Diabetes. Diabetes Care 2016; 39 (Suppl. 01) S13-S22.
    CrossrefPubMedSearch in Google Scholar
  • 14 Capodanno D, Angiolillo DJ. Antithrombotic therapy in patients with chronic kidney disease. Circulation 2012; 125: 2649-2661.
    PubMedSearch in Google Scholar
  • 15 Morel O, Muller C, Jesel L. et al. Impaired platelet P2Y12 inhibition by thienopyridines in chronic kidney disease: mechanisms, clinical relevance and pharmacological options. Nephrol Dial Transplant 2013; 28: 1994-2002.
    CrossrefPubMedSearch in Google Scholar
  • 16 Jankowski V, Günthner T, Herget-Rosenthal S. et al. Dinucleoside polyphosphates and uremia. Semin Dial 2009; 22: 396-399.
    CrossrefPubMedSearch in Google Scholar
  • 17 Chang H, Yanachkov IB, Michelson AD. et al. Agonist and antagonist effects of diadenosine tet-raphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2×1 receptors. Thromb Res 2010; 125: 159-165.
    CrossrefPubMedSearch in Google Scholar