Atypical venous thromboses in myeloproliferative neoplasias

C. Dicke; A. Frölich; K. Holstein; C. Bokemeyer; F. Langer

doi:10.12687/phleb2292-6-2015

Phlebologie, Table of Contents

Phlebologie 2015; 44(06): 324-329
DOI: 10.12687/phleb2292-6-2015

Thrombose und Onkologie: Kasuistik

Schattauer GmbH

Atypical venous thromboses in myeloproliferative neoplasias

Atypische venöse Thrombosen bei myeloproliferativen Neoplasien

C. Dicke

¹II. Medizinische Klinik und Poliklinik, Hubertus Wald Tumorzentrum – Universitäres Cancer Center Hamburg (UCCH), Universitätsklinikum Eppendorf, Hamburg, Germany

,

A. Frölich

²Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Eppendorf, Hamburg, Germany

,

K. Holstein

¹II. Medizinische Klinik und Poliklinik, Hubertus Wald Tumorzentrum – Universitäres Cancer Center Hamburg (UCCH), Universitätsklinikum Eppendorf, Hamburg, Germany

,

C. Bokemeyer

¹II. Medizinische Klinik und Poliklinik, Hubertus Wald Tumorzentrum – Universitäres Cancer Center Hamburg (UCCH), Universitätsklinikum Eppendorf, Hamburg, Germany

,

F. Langer

¹II. Medizinische Klinik und Poliklinik, Hubertus Wald Tumorzentrum – Universitäres Cancer Center Hamburg (UCCH), Universitätsklinikum Eppendorf, Hamburg, Germany

› Author Affiliations

Abstract

Summary

We describe two patients who developed an extensive catheter-related upper extremity deep vein thrombosis and a cerebral venous sinus thrombosis, respectively. Both thrombotic complications occurred in the presence of an elevated platelet count. Subsequent detection of the JAK2 V617F and MPL mutations led to the diagnosis of a myeloproliferative neoplasia.

Zusammenfassung

Wir berichten über zwei Patienten, die eine ausgedehnte Katheter-assoziierte tiefe Venenthrombose der oberen Extremität bzw. eine intrakranielle Sinusthrombose entwickelten. In beiden Fällen war zum Zeitpunkt der Thrombose eine erhöhte Thrombozytenzahl auffällig. Der Nachweis einer JAK2 V617F-Mutation im ersten und einer MPL-Mutation im zweiten Fall führte zur Diagnose einer myeloproliferativen Neoplasie.

Keywords

Catheter-related upper extremity deep vein thrombosis - cerebral venous sinus thrombosis - thrombocytosis - JAK2 V617F mutation - MPL mutation - myeloproliferative neoplasias - essential thrombocythemia - polycythemia vera

Schlüsselwörter

Katheter-assoziierte tiefe Venenthrombose der oberen Extremität - Sinusthrombose - JAK2 V617F-Mutation - MPL-Mutation - myeloproliferative Neoplasien - essenzielle Thrombo -zythämie - Polycythaemia vera

Full Text

References

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