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DOI: 10.12687/phleb2292-6-2015
Atypical venous thromboses in myeloproliferative neoplasias
Atypische venöse Thrombosen bei myeloproliferativen NeoplasienPublication History
Received:
11 October 2015
Accepted:
19 October 2015
Publication Date:
05 January 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00034913/201506/lookinside/thumbnails/10-12687-phleb2292-6-2015-1.jpg)
Summary
We describe two patients who developed an extensive catheter-related upper extremity deep vein thrombosis and a cerebral venous sinus thrombosis, respectively. Both thrombotic complications occurred in the presence of an elevated platelet count. Subsequent detection of the JAK2 V617F and MPL mutations led to the diagnosis of a myeloproliferative neoplasia.
Zusammenfassung
Wir berichten über zwei Patienten, die eine ausgedehnte Katheter-assoziierte tiefe Venenthrombose der oberen Extremität bzw. eine intrakranielle Sinusthrombose entwickelten. In beiden Fällen war zum Zeitpunkt der Thrombose eine erhöhte Thrombozytenzahl auffällig. Der Nachweis einer JAK2 V617F-Mutation im ersten und einer MPL-Mutation im zweiten Fall führte zur Diagnose einer myeloproliferativen Neoplasie.
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