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DOI: 10.12687/phleb2381-4-2017
What phlebologists need to know about geriatric medicine
Artikel in mehreren Sprachen: English | deutschPublikationsverlauf
Received:
16. Juni 2017
Accepted:
20. Juni 2017
Publikationsdatum:
05. Januar 2018 (online)
Summary
Superimposed comorbidities and geriatric syndromes not only make the investigation and diagnosis of elderly and very old patients more difficult, but also present a considerable challenge to treatment, especially with regard to pharmacotherapy. Besides experiencing the physiological effects of ageing, these patents show the highest exposure to medication. At the same time, the number of doctors involved in their treatment increases, which generally results in an incomplete knowledge of all the drugs being taken. In the context of phlebological treatment, it is therefore helpful to know about the most important potentially risky medications, especially where anticoagulants are concerned, and about possible hazardous interactions with ECG changes. If the compatibility of a particular combination is not known, an electronic drug interaction check should always be carried out.
Starting elderly patients at a low dosage and slowly titrating the dose to reach the target dose is a useful therapeutic principle, so that the altered distribution volumes and elimination capacity can be taken into account. An exception is made for antibiotic therapy, in which case the first dose should not be reduced, so that adequate serum levels can be achieved at an early stage.
If treatment fails, the possibility of unintentional non-compliance due to mild cognitive impairment must always be considered and assessed if necessary. The early integration of geriatric treatment concepts should be considered to avoid everyday functional restrictions.
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References
- 1 Fried LP, Xue QL, Cappola AR. et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women. J Gerontol A Biol Sci Med Sci 2009; 64 (Suppl. 10) 1049-1057.
- 2 Inouye SK. et al. Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 2007; 55 (Suppl. 05) 780-791.
- 3 Alexandre TS. et al. Accuracy of Timed Up and Go Test for screening risk of falls among community-dwelling elderly. Rev Bras Fisioter 2012; 16 (Suppl. 05) 381-388. Epub 2012 Aug 2.
- 4 Lee J. et al. Analytical review: focus on fall screening assessments. PM R 2013; 5 (Suppl. 07) 609-621.
- 5 Blasco P. et al. Clinical characteristics, beliefs, and coping strategies among older patients with over-active bladder. Neurol Urodyn 2017; 36 (Suppl. 03) 774-779.
- 6 Ricci JA. et al. Coping strategies and health care-seeking behavior in a US national sample of adults with symptoms suggestive of overactive bladder. Clin Ther 2001; 23 (Suppl. 08) 1245-1259.
- 7 Mills P, Gray D, Krassioukov A. Five things to know about orthostatic hypotension and aging. J Am Geriatr Soc 2014; 62 (Suppl. 09) 1822-1823.
- 8 Campbell NL. et al. Self-Reported Medication Adherence Barriers Among Ambulatory Older Adults with Mild Cognitive Impairment. Pharmacotherapy 2016; 36 (Suppl. 02) 196-202.
- 9 Elliott RA. et al. Ability of older people with dementia or cognitive impairment to manage medicine regimens: a narrative review. Curr Clin Pharmacol 2015; 10 (Suppl. 03) 213-221.
- 10 Grandt D, Schubert I. Analysen zur Arzneimitteltherapie und Arzneimittelsicherheit. In: BEK Arzneimittelreport 2016, Band 39, Berlin.
- 11 Albengres E, Le Louët H, Tillement JP. Systemic antifungal agents. Drug interactions of clinical significance. Drug Saf 1998; 18 (Suppl. 02) 83-97.
- 12 Preissner SC. et al. Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy. PLoS One 2013; 8 (Suppl. 12) e82562.
- 13 Hayes BD. et al. Polypharmacy and the geriatric patient. Clin Geriatr Med 2007; 23 (Suppl. 02) 371-390.
- 14 Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). ,,/clinpharm/ddis/ clinical-table/“, Stand 1.6.2017.
- 15 Lund M, Petersen TS, Dalhoff KP. Clinical Implications of P-Glycoprotein Modulation in Drug-Drug Interactions. Drugs 2017; 77 (Suppl. 08) 859-883.
- 16 Cheong EJ, Goh JJ, Hong Y. et al. Application of Static Modeling in the Prediction of In Vivo Drug-Drug Interactions between Rivaroxaban and Anti-arrhythmic Agents Based on In Vitro Inhibition Studies. Drug Metab Dispos 2017; 45 (Suppl. 03) 260-268.
- 17 Focks J. et al. Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation: post hoc analysis of the ARISTOTLE trial. BMJ 2016; 353: i2868.