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Tierarztl Prax Ausg K Kleintiere Heimtiere 2017; 45(05): 337-343
DOI: 10.15654/TPK-160851
Case Report
Schattauer GmbH

Cutaneous alternariosis in an immunocompromised dog successfully treated with cold plasma and cessation of immunosuppressive medication

Kutane Alternariose eines immunsupprimierten Hundes erfolgreich behandelt mit Kaltplasma und Absetzen der immunsuppressiven Therapie
Janine Classen
1   Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians University, Munich, Germany
,
Berrett Dengler
1   Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians University, Munich, Germany
,
Christoph J. Klinger
1   Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians University, Munich, Germany
,
Sonya V. Bettenay
2   Tierdermatologie Deisenhofen, Oberhaching, Germany
,
Volker Rickerts
3   Robert Koch Institute, Berlin, Germany
,
Ralf S. Mueller
1   Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians University, Munich, Germany
› Author Affiliations
Further Information

Publication History

Received: 22 September 2016

Accepted after revision: 19 January 2017

Publication Date:
09 January 2018 (online)

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Summary

A cutaneous infection with Alternaria spp. was diagnosed in a 2-yearold male intact Irish setter dog, presenting with multifocal papules, plaques and ulcerations involving all four distal limbs, shoulder blades, scrotum, pinnae and nasal mucous membranes. The dog had been treated for inflammatory bowel disease and lymphangiectasia with immunosuppressive doses of cyclosporine and prednisolone for approximately 3 months. The diagnosis was based on clinical signs, the demonstration of fungal elements within skin biopsies, deep fungal culture and fungal PCR from a formalin-fixed tissue specimen. Complete clinical remission was achieved by tapering and cessation of the immunosuppressive medication, treatment with cold atmospheric-pressure plasma (CAPP) and topical enilconazole within 8 weeks.

Zusammenfassung

Bei einem 2 Jahre alten, männlich intakten Irish Setter wurde eine kutane Infektion mit Alternaria spp. diagnostiziert. Der Hund zeigte Papeln, Plaques und Ulzerationen an allen distalen Gliedmaßen, Schulterblättern, Skrotum, Pinnae und nasalen Schleimhäuten. Das Tier erhielt seit ca. 3 Monaten immunsuppressive Dosen von Ciclosporin und Prednisolon zur Behandlung einer chronisch-entzündlichen Darmerkrankung und Lymphangiektasie. Die Diagnose wurde anhand der klinischen Symptomatik, dem Vorliegen von Pilzelementen in Hautbioptaten, einer Pilzkultur aus tiefen Gewebeproben sowie einer PCR-Untersuchung von formalinfixiertem Gewebe auf Pilze gestellt. Durch Absetzen der immunsuppressiven Therapie nach Dosisreduktion sowie topische Behandlung mit Kaltplasma und Enilkonazol ließ sich innerhalb von 8 Wochen eine komplette klinische Remission erreichen.

Keywords

Canine - Alternaria infection - skin - kINPen® VET - therapy

Schlüsselwörter

Kanin - Alternaria-Infektion - Haut - kINPen® VET - Therapie
 

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