Correlation between the FCEAI and diagnostic para meters in chronic enteropathies in 147 cats (2006–2012)

Stefanie Mitze; Katharina Moser; Erik Teske; Wolf v. Bomhard; Christian Stockhaus

doi:10.15654/TPK-170089

Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, Table of Contents

Tierarztl Prax Ausg K Kleintiere Heimtiere 2017; 45(06): 390-396
DOI: 10.15654/TPK-170089

Original Article

Schattauer GmbH

Correlation between the FCEAI and diagnostic para meters in chronic enteropathies in 147 cats (2006–2012)

Korrelation zwischen dem FCEAI und diagnostischen Parametern bei 147 Katzen mit chronischen Enteropathien (2006–2012)

Stefanie Mitze

¹Small Animal Clinic Haar, Haar, Germany

,

Katharina Moser

¹Small Animal Clinic Haar, Haar, Germany

,

Erik Teske

²Department of Clinical Science of Companion Animals, University of Utrecht, The Netherlands

,

Wolf v. Bomhard

³Speciality Practice for Veterinary Pathology, Munich, Germany

,

Christian Stockhaus

¹Small Animal Clinic Haar, Haar, Germany

› Author Affiliations

Abstract

Summary

Objective: The Feline Chronic Enteropathy Activity Index (FCEAI) has been established as a quantitative index for disease activity in chronic enteropathies in cats. A definite diagnosis is aimed at histology with initial exclusion of extraintestinal causes by laboratory examinations, diagnostic imaging and endoscopy. The study aimed to examine diagnostic parameters and FCEAI in chronic gastroenteropathies. Materials and methods: A retrospective case review of 147 cats with chronic enteropathies was performed. In all patients, the FCEAI was established and endoscopy performed including biopsies and duodenal cytology. Histopathologic reports were reviewed for the diagnosis of lymphoma and architectural changes (epithelial integrity, villi/ gland atrophy, intestinal crypt atrophy, lymphangiectasia, epitheliotropism/infiltration of intraepithelial lymphocytes). A cytopathologic score (CS) and histopathologic score (HS) regarding lymphocytic intestinal infiltration were assigned. Statistical dependency analysis was used to determine correlations between the FCEAI, lymphoma, architectural changes, CS, HS, serum concentrations of cobalamin, folate and albumin. Results: The 147 cats consisted of predominately European Shorthair cats (n = 126), were mostly castrated (n = 127) and had a mean age of 9.8 (1–17) years. For the proven lymphoma group (12.2%; n = 18) and the non-lymphoma group a mean FCEAI of 7.3 (4–17) and 6.6 (2–13), respectively, was established. The FCEAI showed a low correlation with the CS (p = 0.010; R = 0.22) and intestinal villous atrophy (n = 121; p = 0.035; R = 0.19). Cats with a CS of 0 had a significant lower FCEAI score (p = 0.015) than cats with all other CSs. The histo- and cytopathologic scores were highly related (p < 0.001; R = 0.43). The gastric intraepithelial lymphocytic infiltration (n = 131) was significantly correlated to serum folate (p = 0.014; R = –0.56) and albumin (p = 0,048; R = –0.20). Conclusion: The FCEAI showed only a few correlations. Not only the grade of inflammation, but also the histologic architectural changes are of importance.

Zusammenfassung

Gegenstand: Der Feline Chronic Enteropathy Activity Index (FCEAI) wurde als quantitativer Index für die Entzündungsintensität bei chronischen Gastroenteropathien der Katze entwickelt. Eine Diagnose wird durch Ausschluss extraintestinaler Erkrankungen anhand von Labor- und bildgebenden Untersuchungen, Endoskopie und Gewebe diagnostik erzielt. Die Studie hatte zum Ziel, die Korrelation von dia gnostischen Parametern und FCEAI bei chronischen Gastroenteropathien zu evaluieren. Material und Methoden: Retrospektive Studie bei 147 Katzen mit chronischen Gastroenteropathien und endoskopisch gewonnenen Bioptaten für die zytologische/histologische Untersuchung. Histologische Befunde wurden auf Entzündungszellinten sität und Architekturveränderungen (Epithelintegrität, Villi-/Drüsenatrophie, Kryptenatrophie, Lymphangiektasie, Epitheltropismus/ intra epitheliale Lymphozyten) untersucht. Bezüglich der lymphoplasmazellulären Zellinfiltration wurden der zytopathologische (ZG) und histopathologische Grad (HG) berücksichtigt. Zur Ermittlung der Korrela tion zwischen FCEAI, Architekturveränderungen, ZG, HG und Serumkonzentration von Cobalamin, Folat und Albumin diente eine statistische Dependenzanalyse. Ergebnisse: Bei den 147 Patienten handelte es sich vorwiegend um Europäisch-Kurzhaar-Katzen (n = 126), meist kastriert (n = 127) mit einem mittleren Alter von 9,8 (1–17) Jahren. Der durchschnittliche FCEAI betrug 7,3 (4–17) für die Lym phomgruppe (12,2%; n = 18) und 6,6 (2–13) für die Nichtlymphomgruppe. Der FCEAI zeigte eine niedrige Korrelation mit dem ZG (p = 0,010; R = 0,22) und der Villiatrophie des Dünndarmepithels (n = 121; p = 0,035; R = 0,19). Katzen mit einem ZG von 0 hatten einen signifikant niedrigeren FCEAI (p = 0,015) als Tiere mit alle ande ren ZG. Zwischen HG und ZG bestand eine hohe Korrelation (p < 0,001; R = 0,43). Die intraepitheliale lymphozytäre Zellinfiltration des Magens (n = 131) war signifikant mit der Folat- (p = 0,014; R = –0,56) und Albuminkonzentration (p = 0,048; R = –0,20) korreliert. Schlussfolgerung: Der FCEAI korrelierte nur teilweise mit anderen Parametern. Neben dem Entzündungsgrad sollten Architekturveränderungen der Darmwand berücksichtigt werden.

Keywords

FCEAI - IBD - lymphoma - cytology - histology

Schlüsselwörter

FCEAI - IBD - Lymphom - Zytologie - Histologie

Full Text

References

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