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Nuklearmedizin 2011; 50(04): 155-156
DOI: 10.3413/Nukmed-0371-10-12
Review
Schattauer GmbH

In vivo imaging neurotransmitter function

The rat 6-hydroxydopamine model and its relevance for human Parkinson’s diseaseIn-vivo-Bildgebung der NeurotransmitterfunktionDas Ratten-6-Hydroxydopamin-Modell in seiner Bedeutung für die Parkinson-Erkrankung des Menschen
S. Nikolaus
1   Clinic of Nuclear Medicine, University Hospital Düsseldorf, Germany
,
R. Larisch
2   Clinic of Nuclear Medicine, Clinic of Lüdenscheid, Germany
,
H. Vosberg
1   Clinic of Nuclear Medicine, University Hospital Düsseldorf, Germany
,
M. Beu
1   Clinic of Nuclear Medicine, University Hospital Düsseldorf, Germany
,
H. Hautzel
1   Clinic of Nuclear Medicine, University Hospital Düsseldorf, Germany
,
A. Wirrwar
1   Clinic of Nuclear Medicine, University Hospital Düsseldorf, Germany
,
H.-W. Mueller
1   Clinic of Nuclear Medicine, University Hospital Düsseldorf, Germany
,
C. Antke
1   Clinic of Nuclear Medicine, University Hospital Düsseldorf, Germany
› Author Affiliations
Further Information

Publication History

received: 06 December 2010

accepted in revised form: 14 February 2011

Publication Date:
28 December 2017 (online)

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Summary

This article gives an overview of those small animal imaging studies which have been conducted on neurotransmitter function in the rat 6-hydoxydopamine (6-OHDA) model of Parkinson’s disease, and discusses findings with respect to the outcome of clinical studies on Parkinsonian patients.

Zusammenfassung

Diese Arbeit gibt eine Übersicht über die bildgebenden Untersuchungen zur Neurotransmitterfunktion, die am 6-Hydroxydopamin- Modell der Ratte durchgeführt wurden. Die Befunde werden im Hinblick auf die Ergebnisse klinischer Studien an Patienten mit Morbus Parkinson diskutiert.

Keywords

Parkinson's disease - PET - SPECT - dopamine - 6-hydroxydopamine model - small animal imaging

Schlüsselwörter

Morbus Parkinson - PET - SPECT - Dopamin - 6-Hydroxydopamin-Modell - Kleintierbildgebung
 

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