Influence of Parameter Settings in Voxel-based Morphometry 8

M. Goto; O. Abe; S. Aoki; N. Hayashi; T. Miyati; H. Takao; H. Matsuda; F. Yamashita; T. Iwatsubo; H. Mori; A. Kunimatsu; K. Ino; K. Yano; K. Ohtomo; for Japanese Alzheimer’s Disease Neuroimaging Initiative

doi:10.3414/ME14-01-0049

Methods of Information in Medicine, Table of Contents

Methods Inf Med 2015; 54(02): 171-178
DOI: 10.3414/ME14-01-0049

Original Articles

Schattauer GmbH

Influence of Parameter Settings in Voxel-based Morphometry 8

Using DARTEL and Region-of-interest on Reproducibility in Gray Matter Volumetry

M. Goto

¹Department of Radiological Technology, University of Tokyo Hospital, Tokyo, Japan

,

O. Abe

²Department of Radiology, Nihon University School of Medicine, Tokyo, Japan

,

S. Aoki

³Department of Radiology, Juntendo University, Tokyo, Japan

,

N. Hayashi

⁴Department of Computational Diagnostic Radiology and Preventive Medicine, University of Tokyo Hospital, Tokyo, Japan

,

T. Miyati

⁵Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan

,

H. Takao

⁶Department of Radiology, University of Tokyo Hospital, Tokyo, Japan

,

H. Matsuda

⁷Department of Nuclear Medicine, Saitama Medical University International Medical Center, Saitama, Japan

,

F. Yamashita

⁸Department of Radiology, National Center Hospital of Neurology and Psychiatry, Japan

,

T. Iwatsubo

⁹Department of Neuropathology, University of Tokyo Hospital, Tokyo, Japan

,

H. Mori

⁶Department of Radiology, University of Tokyo Hospital, Tokyo, Japan

,

A. Kunimatsu

⁶Department of Radiology, University of Tokyo Hospital, Tokyo, Japan

,

K. Ino

¹Department of Radiological Technology, University of Tokyo Hospital, Tokyo, Japan

,

K. Yano

¹Department of Radiological Technology, University of Tokyo Hospital, Tokyo, Japan

,

K. Ohtomo

⁶Department of Radiology, University of Tokyo Hospital, Tokyo, Japan

,

for Japanese Alzheimer’s Disease Neuroimaging Initiative

› Author Affiliations

Abstract

Summary

Objectives: To investigate whether reproducibility of gray matter volumetry is influenced by parameter settings for VBM 8 using Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) with region-of-interest (ROI) analyses.

Methods: We prepared three-dimensional T1-weighted magnetic resonance images (3D-T1WIs) of 21 healthy subjects. All subjects were imaged with each of five MRI systems. Voxel-based morphometry 8 (VBM 8) and WFU PickAtlas software were used for gray matter volumetry. The bilateral ROI labels used were those provided as default settings with the software: Frontal Lobe, Hippocampus, Occipital Lobe, Orbital Gyrus, Parietal Lobe, Putamen, and Temporal Lobe. All 3D-T1WIs were segmented to gray matter with six parameters of VBM 8, with each parameter having between three and eight selectable levels. Reproducibility was evaluated as the standard deviation (mm³) of measured values for the five MRI systems.

Results: Reproducibility was influenced by ‘Bias regularization (BiasR)’, ‘Bias FWHM’, and ‘De-noising filter’ settings, but not by ‘MRF weighting’, ‘Sampling distance’, or ‘Warping regularization’ settings. Reproducibility in BiasR was influenced by ROI. Superior reproducibility was observed in Frontal Lobe with the BiasR1 setting, and in Hippocampus, Parietal Lobe, and Putamen with the BiasR3*, BiasR1, and BiasR5 settings, respectively.

Conclusion: Reproducibility of gray matter volumetry was influenced by parameter settings in VBM 8 using DARTEL and ROI. In multi-center studies, the use of appropriate settings in VBM 8 with DARTEL results in reduced scanner effect.

Keywords

Atlas-based method - gray matter volumetry - effect of scanner - reproducibility - statistical parametric mapping

Full Text

References

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