Bilio-cutaneous fistula obliteration with NBCA

Abstract

Biliary fistula and bile leakage are complications that can occur during hepato-biliary surgery (both open and laparoscopic) and percutaneous biliary intervention. In some cases, spontaneous resolution is documented but more often re-intervention (surgical or percutaneous) is necessary. We present the case of a male patient who underwent right hepatectomy with bilio-digestive anastomosis for a cholangiocarcinoma which developed a bilo-cutaneous fistula through the path of a previously inserted percutaneous transhepatic drainage. Sealing of bilo-cutaneous fistula was obtained using N-butil-Cyanoacrylate. This technique has already been reported in some papers as a useful tool for biliary tree obliteration; however, to our knowledge, no cases describing the use of glue to seal a sub-cutaneous route are available in literature.

Keywords

Biliary tree - cholangiography - fistula - NBCA - obliteration

Case Report

A 72-year-old man affected by cholangiocarcinoma (Klatskin 3a) who underwent right hepatectomy with a biliodigestive anastomosis (Roux-en-Y), was referred to our Department to perform a 1-year follow-up MRI scan.

MRI showed intrahepatic biliary dilation caused by stenosed anastomosis. Multidisciplinary board decided for percutaneous bilioplasty. PTBD was positioned through left access.

A month later, biliary drainage revision was necessary because of bile leakage through cutaneous access of PTBD. Conservative treatment was chosen; therefore, replacement of biliary drainage with higher French scaling was successfully performed. PTBD was removed 3 months later after a normal cholangiogram.

Within 8 days from PTBD removal, biliary leakage of 150 cc/day re-appeared, compelling the placement of a new PTC under US guidance through left biliary system was performed.

Cholangiography showed a biliocutaneous fistula at the entry site of previous PTBD [[Figure 1]].

Figure 1: Cholangiography made through an angiographic catheter show the fistula (white arrows) and the leakage (black arrow) at the entry site of previous PTBD

The point of leakage was then reached through biliary tree with a 0.035” hydrophilic guidewire (Radifocus® Guidewire M Standard type, Terumo, Tokyo, Japan) and a multipurpose 4F vascular catheter (Cordis, Fremont, California); a mixture of Lipiodol (Guerbet, Villepinte, France) and N-butyl-Cyanocrylate (Glubran 2, GEM, Italy) was then injected [[Figure 2]].

Figure 2: Selective catheterization of the fistula followed by injection of a mixture of Lipiodol and NBCA

The final cholangiography demonstrated complete obliteration of the fistula and no more bile leakage was observed [[Figure 3A] and [B]].

Figure 3 (A and B): The final cholangiography shows complete sealing of the fistula (A); with digital subtraction the mold of glue (black arrows) along the path is better appreciable (B)

Patient was discharged after 3 days and no recurrence was documented during the 3 months follow-up.

Discussion

Biliary fistula and bile leakage are complications that may occur during hepato-biliary surgery (both open and laparoscopic) and percutaneous biliary interventions.[[1],[2],[3]]

Variations in biliary anatomy can increase the risk of ductal injuries.

Adequate pre-operatory imaging evaluation (CT and/or MRCP) may reduce the incidence of bile duct injury with occurrence of leakage.[[4],[5]]

Damaged bile ducts (isolated or communicating with the main biliary tree) may leak directly into the abdomen from the time of intervention or develop fistulas through thoracic wall to the skin, along percutaneous transhepatic drainage (PTBD).[[1]]

Acute injuries may not be detected immediately during procedures, enduring silently, resolve spontaneously or they can reveal as bile peritonitis, prolonged time of wound healing and lately with malabsorption.[[6],[7]]

The high rate of morbidity and mortality related to surgical reoperation in such delicate patients making endoscopic and interventional radiology techniques the best choice treatments.[[8],[9],[10]]

Development of cutaneous biliary leakage is a well-known and frequent complication that occurs in patients who keep PTBD catheters in place for a long time. The occurrence of secondary obstructions to bile discharge (e.g., debris, malignant stenosis) represent a constant cause of bile spreading in the space between the catheter and surrounding tissues.

Usually this condition is solved by removing the cause of obstruction, but in many cases bile leakage persist or, more often, no clear evidence of a possible cause is found, with a good antegrade bile drainage to duodenum at percutaneous cholangiography (PTC).

In other conditions a normal cholangiogram would suggest PTBD removal and patient discharge but in the presence of a cutaneous leakage the first option is the insertion of a larger PTBD with more discomfort and longer time of hospitalization for the patient.

Different materials have already been studied and tested to seal the biliary tract, in particular fibrin,[[11]] ethanol,[[12]] and NBCA.[[1],[2],[13],[14],[15],[16]]

These studies, based on case reports or small series, demonstrated that the latter is safer and more effective.

Due to its efficacy on biliary tree, in addition on its established role as embolic agent in different endovascular procedures,[[17],[18],[19]] we decided to use NBCA to treat our patient.

We have found no literature cases in which the glue was used to seal a sub-cutaneous route; in conclusion we find that NBCA can be successfully employed in this field in order to improve patient comfort and shorten hospital stay.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Conflict of Interest

There are no conflicts of interest.

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Publication History

Received: 29 January 2019

Accepted: 05 June 2019

Article published online:
22 July 2021