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Hamostaseologie 2014; 34(03): 233-236
DOI: 10.5482/HAMO-14-03-0020
Case report
Schattauer GmbH

Massive pulmonary embolism in a young boy with T-cell leukaemia

Successful thrombolytic therapy by recombinant tissue plasminogen activator (rtPA)Massive Lungenembolie bei einem kleinen Jungen mit akuter T-Zell-LeukämieErfolgreiche Thrombolyse mit rekombinantem gewebespezifischen Plasminogenaktivator (rtPA)
O. Beck
1   Oncology & Haemostaseology, Children’s Hospital, Paediatric Haematology, University Medical Center, Johannes Gutenberg-University Mainz
,
C. Martin
2   Paediatric Cardiology, Children’s Hospital, University Medical Center, Johannes Gutenberg-University Mainz
,
F. Alt
1   Oncology & Haemostaseology, Children’s Hospital, Paediatric Haematology, University Medical Center, Johannes Gutenberg-University Mainz
,
A. Wingerter
1   Oncology & Haemostaseology, Children’s Hospital, Paediatric Haematology, University Medical Center, Johannes Gutenberg-University Mainz
,
G. Staatz
3   Department of Diagnostic and Interventional Radiology, Paediatric Radiology, University Medical Center, Johannes Gutenberg-University Mainz
,
H. Schinzel
4   Center for Thrombosis and Haemostasis, University Medical Center Mainz of Johannes Gutenberg-University Mainz, Germany
,
J. Faber
1   Oncology & Haemostaseology, Children’s Hospital, Paediatric Haematology, University Medical Center, Johannes Gutenberg-University Mainz
› Author Affiliations
Further Information

Publication History

received: 19 March 2014

accepted in revised form: 17 June 2014

Publication Date:
28 December 2017 (online)

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Summary

Acute pulmonary embolism (PE) is a serious complication in association with malignant diseases. We describe the successful treatment of PE applying a systemic thrombolytic therapy in a 4-year-old boy with acute lymphoblastic leukaemia.

The thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) 0.1 mg/ kg bodyweight per hour for six hours was continued for six days without important side effects. In particular no bleeding complications were observed. Computed tomography with contrast revealed a remarkable regression of the central PE. Without further delays the chemotherapy was resumed.

Zusammenfassung

Eine akute Lungenembolie (LE) ist eine ernste Komplikation bei onkologischen Erkrankungen. Wir berichten über die erfolgreiche Behandlung einer LE unter Anwendung einer systemischen thrombolytischen Therapie bei einem vierjährigen Jungen mit akuter lymphatischer Leukämie.

Die Thrombolyse wurde mit rtPA (recombinant tissue plasminogen activator) 0,1 mg/kg Körpergewicht pro Stunde für sechs Stunden über sechs Tage ohne nennenswerte Nebenwirkungen durchgeführt. Insbesondere wurden keine Blutungskomplikationen beobachtet. Eine Kontrolle mittels Computertomographie ergab einen bemerkenswerten Rückgang der zentralen LE. Die Chemotherapie konnte ohne Verzögerungen fortgesetzt werden.

Keywords

Pulmonary embolism - leukaemia - recombinant tissue plasminogen activator - rtPA - children

Schlüsselwörter

Lungenembolie - Leukämie - rtPA - Kinder
 

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