Multiple receptor-mediated functions of activated protein C

H. Weiler

doi:10.5482/ha-1166

Hämostaseologie, Table of Contents

Hamostaseologie 2011; 31(03): 185-195
DOI: 10.5482/ha-1166

Review

Schattauer GmbH

Multiple receptor-mediated functions of activated protein C

Rezeptor-vermittelte Funktionen von aktiviertem Protein C

H. Weiler

¹Blood Research Institute, BloodCenter of Wisconsin, Milwaukee

› Author Affiliations

Abstract

Summary

The central effector protease of the protein C pathway, activated protein C (APC), interacts with the endothelial cell protein C receptor, with protease activated receptors (PAR), the apolipoprotein E2 receptor, and integrins to exert multiple effects on haemostasis and immune cell function. Such receptor interactions modify the activation of PC and determine the biological response to endogenous and therapeutically administered APC. This review summarizes the current knowledge about interactions of APC with cell surface-associated receptors, novel substrates such as histones and tissue factor pathway inhibitor, and their implications for the biologic function of APC in the control of coagulation and inflammation.

Zusammenfassung

Die im Zentrum des natürlichen Protein-C-Antikoagulans-Mechanismus stehende Protease, aktiviertes Protein C (APC), interagiert mit verschiedenen Rezeptoren, wie dem Endothelzell-Protein-C-Rezeptor, Proteaseaktivierten Rezeptoren (PAR), dem Apolipoprotein-E2-Rezeptor und Integrinen, was zu multiplen Wirkungen des Enzyms in der Hämostase und im Immunsystem führt. Solche unterschiedlichen Rezeptor-Wechselwirkungen können nicht nur die Aktivierung von Protein C beeinflussen, sondern determinieren auch die biologischen Funktionen von endogenem und therapeutisch eingesetztem APC.

Diese Übersicht fasst die aktuelle Datenlage zu Interaktionen des APC mit zellulären Rezeptoren, neuen Substraten (wie nuklearen Histonen) und Inhibitoren (z. B. Tissue Factor Pathway Inhibitor) zusammen und diskutiert Konsequenzen für die biologischen Funktionen von APC in der Kontrolle der Blutgerinnung und des Entzündungsgeschehens.

Keywords

Activated protein C - protein C - anticoagulation - cell signaling - protease activated receptors - apoER2 - integrin

Schlüsselwörter

Aktiviertes Protein C - Protein C - Gerinnungshemmung - Zellsignale - Protease-aktivierte Rezeptoren - apoER2 - Integrin

Full Text

References

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