Platelets in cancer

E. Mammadova-Bach; P. Mangin; F. Lanza; F. Gachet

doi:10.5482/hamo-14-11-0065

Hämostaseologie, Inhaltsverzeichnis

Hamostaseologie 2015; 35(04): 325-336
DOI: 10.5482/hamo-14-11-0065

Review

Schattauer GmbH

Platelets in cancer

From basic research to therapeutic implicationsBlutplättchen und KrebsVon der Grundlagenforschung zur therapeutischen Relevanz

Autor*innen

E. Mammadova-Bach

¹UMR_S949, Inserm, Strasbourg, France; Etablissement Français du Sang-Alsace, Strasbourg, France; Université de Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg, France
P. Mangin

¹UMR_S949, Inserm, Strasbourg, France; Etablissement Français du Sang-Alsace, Strasbourg, France; Université de Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg, France
F. Lanza

¹UMR_S949, Inserm, Strasbourg, France; Etablissement Français du Sang-Alsace, Strasbourg, France; Université de Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg, France
F. Gachet

¹UMR_S949, Inserm, Strasbourg, France; Etablissement Français du Sang-Alsace, Strasbourg, France; Université de Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg, France

Abstract

Summary

Platelets are well-known for their major role in primary hemostasis and thrombosis. Cancer patients frequently manifest thrombotic events and present abnormalities in blood coagulation which appear to be linked to altered platelet function and turnover. Moreover, numerous studies indicate an intimate cross-talk between platelets and tumor growth, angiogenesis and metastatic dissemination. Finally, several experimental data and clinical trials suggest possible benefits of anti-platelet drugs on some cancers. Here, we will review the current state of basic biological research regarding the role of platelets in cancer progression. We also critically review the possible clinical applicability of some anti-platelet therapies to limit tumor growth and prevent metastatic dissemination.

Zusammenfassung

Die wichtige Rolle der Plättchen in der primären Hämostase und Thrombose ist gut bekannt. Krebspatienten weisen häufig thrombotische Ereignisse und Unregelmäßigkeiten der Blutgerinnung auf, die mit Veränderungen der Plättchenfunktion und des Thrombozyten-Turnover verbunden zu sein scheinen. Außerdem wiesen zahlreiche Studien auf eine enge Wechselwirkungen zwischen Plättchen, Tumorwachstum, Angiogenese und Metastasierung hin. Schließlich lassen experimentelle Daten und klinische Studien einen möglichen Nutzen von Thrombozytenaggregationshemmern bei einigen Krebsarten vermuten.

Wir geben einen Überblick zum aktuellen Stand der biologischen Grundlagenforschung bzgl. der Rolle der Plättchen bei der Krebsprogression. Auch die Eignung einiger Thrombozytenaggregationshemmer zur Eindämmung des Tumorwachstums und zur Prophylaxe der metastatischen Tumorausbreitung haben wir kritisch geprüft.

Keywords

Platelet physiology - cancer - tumor metastasis - anti-platelet agents

Schlüsselwörter

Plättchenphysiologie - Krebs - Tumormetastasen - Thrombozytenaggregationshemmer

Volltext

Referenzen

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