Zeitschrift für Gastroenterologie

Issue 01 · January 2014

eFirst
Issue
30. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Tübingen, 24. – 25. 1. 2014

Kongresspräsident: Prof. Dr. Alfred Königsrainer

Abstracts (HTML) List of Authors
- 5. Virushepatitis, Immunologie
V_5_01
Schröder, D; Churin, Y; Roderfeld, M; Glebe, D; Roeb, E: Cytokeratins 8 and 18 are responsible for distribution and secretion of hepatitis B virus surface proteins FREE ACCESS
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V_5_02
Bohne, F; Meyer, C; Quitt, O; Dhamodaran, A; Alvarez, L; Caballero, S; Guillamet, A; Bruss, V; Moldenhauer, G; Momburg, F; Protzer, U: Immunotherapeutic retargeting of effector cells towards HBV infected target cells using bispecific antibody constructs FREE ACCESS
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V_5_03
Bruns, T; Zimmermann, HW; Li, KK; Trivedi, PJ; Pachnio, A; Reynolds, G; Hubscher, S; Moss, PA; Adams, DH: Virus Infection Of Hepatic Sinusoidal Endothelial Cells Regulates Hepatic T Cell Recruitment And Activation FREE ACCESS
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P_5_01
Martin, B; Bengsch, B; Nitschke, K; Thimme, R; Neumann-Haefelin, C: A protective HLA-B*27 restricted epitope contributes to viral control in chronic HCV infection despite presence of viral escape mutations and is characterized by a unique T cell phenotype FREE ACCESS
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P_5_02
Busch, K; Hoh, A; Thimme, R: Comparison of different inhibitory pathways in hepatitis B virus-specific CD8+ T cell exhaustion FREE ACCESS
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P_5_03
Michler, T; Russo, C; Bach, C; Zhang, K; Bauer, T; Protzer, U: Correlation of fulminant hepatitis B and escape mutations in the 2nd loop of the HBsAg a-determinant FREE ACCESS
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P_5_04
Kefalakes, H; Jochum, C; Bohrer, AM; Hilgard, G; Kahraman, A; El Hindy, N; Heinemann, F; Gerken, G; Timm, J: Decades after spontaneous HBsAg clearance the CD8+ T cell immune response is less vigorous compared to chronic hepatitis B viral infection FREE ACCESS
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P_5_05
Wenzel, JJ; Sichler, M; Schemmerer, M; Behrens, G; Leitzmann, MF; Jilg, W: Decline in Hepatitis E Virus (HEV) Antibody Prevalence in Southeastern Germany, 1996 – 2011 FREE ACCESS
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P_5_06
Giebeler, A; Neumann, U; Brandenburg, LO: Deletion of Formyl-peptide receptors lead to an increased inflammatory response and enhanced liver injury following a bacterial induced hepatitis FREE ACCESS
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P_5_07
Schulze, K; Weismüller, T; Hübener, P; Zenouzi, R; Gotthardt, D; de Leuw, P; Bubenheim, M; Teufel, A; Zimmer, V; Lenzen, H; Reiter, F; Rust, C; Tharun, L; Quaas, A; Lammert, F; Galle, PR; Sarrazin, C; Manns, M; Lohse, AW; Schramm, C: Der Simplified AIH Score – Kriterium zur Einleitung einer Immunsuppression bei Patienten mit Primär Sklerosierender Cholangitis: Ergebnisse einer deutschen Multicenter Studie FREE ACCESS
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P_5_08
Hermanns, NL; Cubero, FJ; Mohs, A; Ohl, K; Al Masaoudi, M; Lietdke, C; Tenbrock, K; Trautwein, C: Die CREMα-abhängige T-Zellantwort hemmt Progression der chronischen Lebererkrankung und deren Komplikationen FREE ACCESS
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P_5_09
Krämer, B; Diegeler, S; Kokordelis, P; Glässner, A; Eisenhardt, M; Wolter, F; Boesecke, C; Goeser, F; Spengler, U; Rockstroh, JK; Nattermann, J: Die HIV-assoziierte Dysregulation der NKp46 Expression auf NK Zellen könnte die Suszeptibilität für HCV und deren Verlauf beeinflussen FREE ACCESS
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P_5_10
Giersch, K; Homs, M; Volz, T; Allweiss, L; Lohse, AW; Buti, M; Petersen, J; Dandri, M; Lütgehetmann, M: Different antiviral effects induced by interferon or entecavir in HDV infected human-chimeric uPA/SCID mice determined by new intrahepatic qRT-PCR assay FREE ACCESS
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P_5_11
Hoh, A; Schuch, A; Ni, Y; Bertoletti, A; Blum, HE; Urban, S; Thimme, R: Dominance of cytolytic effector functions in hepatitis B virus-specific CD8+ T cell and NK cell mediated antiviral efficacy using hepatitis B virus infected hepatocytes overexpressing human sodium taurocholate cotransporting polypeptide FREE ACCESS
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P_5_12
Dammermann, W; Stiel, EM; Kohring, M; Schulze zur Wiesch, J; Lohse, AW; Lüth, S: Easy and robust testing of T cell responsiveness to HBV antigens in whole blood of chronic Hepatitis B patients FREE ACCESS
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P_5_13
Solbach, P; Westhaus, S; Deest, M; Berg, T; Manns, MP; Sarrazin, C; Ciesek, S; Hahn, T von: Endogenous oxidized LDL levels predict treatment response in interferon-based therapy of chronic hepatitis C FREE ACCESS
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P_5_14
Bissinger, AL; Fehrle, C; Werner, CR; Egetemeyr, D; Malek, NP; Berg, CP: Epidemiologische Entwicklung und Genotypisierung von Patienten mit einer chronischer Hepatitis B in Deutschland: Hinweise für einen Rückgang des Genotyp A zu Gunsten des Genotyp D FREE ACCESS
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P_5_15
Dammermann, W; van der Maaden, K; Lüth, S: Expression of myelin auto-antigens and myelin altered peptide ligands in the liver in EAE mice models FREE ACCESS
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P_5_16
Ingiliz, P; Rockstroh, JK; Nelson, M; Soriano, V; Arastéh, K; Guardiola, J; Bhagani, S; Mallolas, J; Tural, C; Puoti, M; Battegay, M; Jain, MK; Nunez, M; Marks, K; Kort, J; Stern, J; Vinisko, R; Manero, M; Dieterich, D: Faldaprevir plus pegyliertes Interferon alpha-2a und Ribavirin (PR) bei Patienten mit HIV und Hepatitis C Genotyp (GT)-1 Koinfektion: End of Treatment Response (ETR) – Ergebnisse der Phase III Studie STARTVerso 4 FREE ACCESS
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P_5_17
Kah, J; Volz, T; Lütgehetmann, M; Lohse, AW; Tiegs, G; Sass, G; Dandri, M: Hemoxygenase-1 and its downstream product Biliverdin suppress HCV replication and provides hepatoprotective effects in humanized uPA/SCID mice FREE ACCESS
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P_5_18
Spitzley, S; Häussinger, D; Bode, JG: Hepatitis C virus induced suppression of IκBζ and interference with IκBζ induced Lipocalin2 Expression FREE ACCESS
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P_5_19
Eisenbürger, S; Häussinger, D; Bode, JG: Hepatitis C virus infection results in a reorganization of the expression pattern of ErbB receptor family members on its host cell FREE ACCESS
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P_5_20
Gröpper, C; Triller, N; Eisenbürger, S; Seifert, CR; Häussinger, D; Bode, JG: Hepatitis C Virus modulates TNFα-induced chemokine production and enables EGF to induce chemokine production in its host cell FREE ACCESS
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P_5_21
Rau, M; Schmitt, J; Kudlich, T; Marin, JJG; Rodríguez Romero, M; Klinker, H; Tony, HP; Müllhaupt, B; Geier, A: Higher frequency of peripheral CD3CXCR3 and CD4CXCR3 positive blood cells in HCV patients in context of bile acid retention FREE ACCESS
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P_5_22
Russo, C; Dembek, C; Geisler, F; Umgelter, A; Draenert, R; Protzer, U; Bauer, T: HIV-1 infection impairs frequency and functionality of HBV-specific CD4 T cells in patients with chronic hepatitis B FREE ACCESS
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P_5_23
Lutterbeck, M; Broering, R; Kleinehr, K; Paul, A; Gerken, G; Schlaak, JF: Human non-parenchymal liver cells produce type I and type III interferons in response to poly I:C, thereby mediating an antiviral state against HCV FREE ACCESS
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P_5_24
Langhans, B; Alwan, AW; Althausen, E; Krämer, B; Glässner, A; Nattermann, J; Strassburg, C; Spengler, U: IL-8 hemmt die Suszeptibilität von CD56hochCD16negativ NK-Zellen gegenüber primären humanen hepatischen Sternzellen (HSC) FREE ACCESS
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P_5_25
Roos, K; Gotthardt, D; Giese, T; Schnitzler, P; Stremmel, W; Czock, D; Eisenbach, C: Immunomonitoring of NFAT-regulated gene expression in liver allograft recipients under telaprevir based hepatitis C therapy reveals significant impact on residual gene activity FREE ACCESS
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P_5_26
Broering, R; Trippler, M; Real, CI; Lutterbeck, M; Kleinehr, K; Poggenpohl, L; Gerken, G; Schlaak, JF: Interferon stimulated gene 15, a proviral factor in hepatitis C virus replication, is regulated by the Proteasome subunit alpha type-6 FREE ACCESS
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P_5_27
Thoens, C; Berger, C; Trippler, M; Siemann, H; Lutterbeck, M; Broering, R; Schlaak, JF; Heinemann, FM; Heinold, A; Nattermann, J; Scherbaum, N; Alter, G; Timm, J: KIR2DL3+ NKG2A- Natural Killer Cells Protect People who Inject Drugs against Productive Hepatitis C Virus Infection FREE ACCESS
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P_5_28
Bovensiepen, C; Sebode, M; Sospedra, M; Martin, R; Lohse, AW; Schramm, C; Herkel, J; Weiler-Normann, C: Leberinfitrierende CD4 T Zellen bei der autoimmunen Hepatitis zeigen ein distinktes TH1 Profil FREE ACCESS
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P_5_29
Karimi, K; Kessler, T; Ramisch, K; Tasika, E; Arck, P; Tiegs, G: Maternal Liver Damage Programs Offspring Allergic Inflammation in Mice FREE ACCESS
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P_5_30
Haxthausen, F von; Schwinge, D; Quaas, A; Huber, S; Herkel, J; Lohse, AW; Schramm, C: Modulation von regulatorischen T Zellen im Mausmodell der Primär Sklerosierenden Cholangitis FREE ACCESS
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P_5_31
Hoyo-Becerra, C; Liu, ZJ; Gerken, G; Hermann, DM; Schlaak, JF: New mouse model mimicking IFN-related depression in HCV patients FREE ACCESS
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P_5_32
Lang, PA; Xu, HC; Grusdat, M; Parish, I; Recher, M; Elford, A; Dhanji, S; Shaabani, N; Tran, CW; Dissanayake, D; Rahbar, R; Ghazarian, M; Brustle, A; Fine, J; Chen, P; Weaver, CT; Klose, C; Diefenbach, A; Carlyle, JR; Kaech, SM; Mak, TW; Ohashi, PS; Häussinger, D; Lang, KS: NK cell activity promotes liver damage and chronic viral infection FREE ACCESS
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P_5_33
Kokordelis, P; Krämer, B; Boesecke, C; Glässner, A; Eisenhardt, M; Voigt, E; Ingiliz, P; Wolter, F; Strassburg, CP; Rockstroh, JK; Spengler, U; Nattermann, J: Phänotypische und funktionelle Analyse von natürlichen Killer T (NKT)-Zellen bei HIV-Patienten mit einer akuten Hepatitis C FREE ACCESS
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P_5_34
Nischalke, HD; Lutz, P; Berger, C; Langhans, B; Hoerauf, A; Grünhage, F; Appenrodt, B; Lammert, F; Nattermann, J; Sauerbruch, T; Strassburg, CP; Spengler, U: Polymorphsims in the farnesoid X receptor modify the risk for spontaneous bacterial peritonitis in cirrhotic patients FREE ACCESS
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P_5_35
Pereira, IVA; Wilson, M; Sarrazin, C; de Oliveira, CPMS; Manns, MP; Ciesek, S; Hahn, T von: Primary but not secondary biliary acids inhibit hepatitis D virus entry into human hepatoma cells expressing the sodium-taurocholate cotransporting polypeptide FREE ACCESS
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P_5_36
Allweiss, L; Volz, T; Giersch, K; Petersen, J; Lohse, AW; Lütgehetmann, M; Dandri, M: Proliferation of hepatitis B virus infected human hepatocytes in humanized mice treated with the entry inhibitor Myrcludex-B induces strong cccDNA reduction and maintenance of cccDNA-free hepatocytes FREE ACCESS
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P_5_37
Brunskole-Hummel, I; Zitzmann, A; Wenzel, J; Jilg, W: Quality of HBsAg-specific immune memory: response to hepatitis-B-revaccination in adolescents 10 – 15 years after immunization in infancy FREE ACCESS
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P_5_38
Wiegand, SB; Bremer, B; Geipel, A; Bremer, CM; Wranke, A; Heidrich, B; Manns, MP; Wedemeyer, H; Glebe, D; Cornberg, M: Quantification of Large, Middle and Small Hepatitis B virus (HBV) surface protein (HBsAg) fractions in patients with Hepatitis Delta FREE ACCESS
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P_5_39
Xu, HC; Mcllwain, DR; Pandyra, AA; Recher, M; Brenner, D; Häussinger, D; Ohashi, PS; Mak, TW; Lang, KS; Lang, PA: Reactive oxygen species delay control of lymphocytic choriomeningitis virus FREE ACCESS
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P_5_40
Martin, B; Hennecke, N; Blum, HE; Kukolj, G; Böcher, WO; Thimme, R: Restoration of Hepatitis C virus-specific CD8+ T-cell responses in patients undergoing IFN-free antiviral therapy FREE ACCESS
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P_5_41
Werner, JM; Serti, E; Chepa-Lotrea, X; Stoltzfus, J; Ahlenstiel, G; Feld, JJ; Liang, JT; Rotman, Y; Rehermann, B: Ribavirin Pretreatment Improves the IFN-γ Response of Natural Killer Cells to IFN-based Therapy of Hepatitis C Virus Infection FREE ACCESS
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P_5_42
Sprinzl, MF; Grambihler, A; Ehrlich, A; Kittner, J; Ebert, M; Zeuzem, S; Cornberg, M; Lohmeyer, J; Tacke, F; Eisenbach, C; Geisler, F; Spengler, U; Schott, E; Galle, PR: Safety of add on Interferon-alpha-2a in hepatitis B patients receiving effective nucleos(t)de therapy: Interim results from the German multicenter PADD-ON trial FREE ACCESS
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P_5_43
Matono, T; Churin, Y; Reinhard, H; Roderfeld, M; Schröder, D; Zahner, D; Glebe, D; Roeb, E: Signaling pathways involved in carcinogenesis in a double hit mouse model of cholangiopathy and hepatitis B virus FREE ACCESS
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P_5_44
Graumann, F; Churin, Y; Roderfeld, M; Schröder, D; Glebe, D; Roeb, E: Spontaner Verlust der Überexpression des großen HBV-Oberflächenproteins schützt Alb1-HBV-transgene Mäuse vor Leberschädigung FREE ACCESS
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P_5_45
Krebs, K; Böttinger, N; Huang, LR; Chmielewski, M; Arzberger, S; Gasteiger, G; Bohne, F; Aichler, M; Uckert, W; Abken, H; Heikenwälder, M; Knolle, P; Protzer, U: T cells redirected by a chimeric antigen receptor efficiently control Hepatitis B Virus replication in an immunocompetent mouse model FREE ACCESS
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P_5_46
Oehler, N; Volz, T; Kah, J; Giersch, K; Allweiss, L; Petersen, J; Lohse, AW; Lütgehetmann, M; Heeren, J; Dandri, M: The expression profile of bile acid and cholesterol synthesis genes are affected by the binding of Hepatitis B Virus to its cellular receptor FREE ACCESS
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P_5_47
Behrendt, P; Dörrbecker, J; Steinmann, E; Hügging, K; Menzel, N; Grabski, E; Rogalska-Taranta, M; Pfaender, S; Kalinke, U; Wedemeyer, H; Manns, MP; Pietschmann, T: The impact of adipokines hormones on HCV life-cycle FREE ACCESS
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P_5_48
Ehlting, C; Trilling, M; Tiedje, C; Zimmermann, A; Le, VTK; Gaestel, M; Hengel, H; Häussinger, D; Bode, JG: The MAPKAP kinase 2 controls IL-10 expression and protects from liver injury upon cytomegalovirus infection FREE ACCESS
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P_5_49
Maasoumy, B; Port, K; Markova, AA; Calle Serrano, B; Sollik, L; Kirschner, J; Mix, C; Manns, MP; Wedemeyer, H; Cornberg, M: Thrombozytenzahl, Albumin und Bilirubin identifizieren Patienten mit chronischer Hepatitis C Zirrhose mit hohem Risiko für ein Therapieversagen und schwerwiegende Nebenwirkungen während einer Triple-Therapie mit Boceprevir oder Telaprevir FREE ACCESS
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P_5_50
Real, CI; Broering, R; Jahn-Hofmann, K; Ickenstein, L; John, M; Kleinehr, K; Driftmann, S; Kemper, T; Vornlocher, HP; Schirmbeck, R; Lu, M; Gerken, G; Schlaak, JF: Toll-like receptor 3 activation mediates the expression of interferon and interferon stimulated genes during hepadnaviral replication in HBV-transgenic mice lacking the HBs-antigen FREE ACCESS
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P_5_51
Kozik, JH; Trautmann, T; Carambia, A; Eissing, L; Lohse, AW; Wiegard, C; Heeren, J; Herkel, J: TREM1-Defizienz begünstigt die vorzeitige Klärung einer Virushepatitis im Mausmodell FREE ACCESS
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P_5_52
Werner, CR; Egetemeyr, DP; Lauer, UM; Malek, NP; Berg, CP: Wirksamkeit und Sicherheit der Triple-Therapie mit Telaprevir bei 102 Patienten mit Hepatitis C, Genotyp 1: SVR 12 Daten FREE ACCESS
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P_5_53
Wehmeyer, MH; Schulze zur Wiesch, J; Eißing, F; Lohse, AW; Lüth, S: Wirksamkeit und Sicherheit der Tripletherapie bei chronischer Hepatitis C Virusinfektion außerhalb kontrollierter Studien FREE ACCESS
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